TRIAL COMPARING METRONIDAZOLE AND FURAZOLIDONE (OMEPRAZOLE, TETRACYCLINE, BISMUTH PLUS METRONIDAZOLE VS FURAZOLIDONE) FOR ERADICATION OF HELICOBACTER PYLORI IN IRANIAN PEPTIC ULCER DISEASE PATIENTS

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KAVIANI M.J.; SARI ASLANI F.; SABERI FIROUZI M.; BORD BAR B.; FATAHI S.J.; TABEEI S.Z.A.D.; MASARAT S.

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Journal: GOVARESH JOURNAL Year:2001 | Volume:5 | Issue:27-28 Page(s): 75-80

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Title

TRIAL COMPARING METRONIDAZOLE AND FURAZOLIDONE (OMEPRAZOLE, TETRACYCLINE, BISMUTH PLUS METRONIDAZOLE VS FURAZOLIDONE) FOR ERADICATION OF HELICOBACTER PYLORI IN IRANIAN PEPTIC ULCER DISEASE PATIENTS

Author(s)

Keywords

HELICOBACTER PYLORIQ3

PEPTIC ULCERQ3

METRONIDAZOLQ3

FURAZOLIDONEQ4

QUADRUPLE ERADICATION THERAPY HELICOBACTER PYLORIQ4

Abstract

Introduction: METRONIDAZOLe resistance may have a very important impact on the eradication rate of HELICOBACTER PYLORI (H pylori) infection in developing countries. FURAZOLIDONE is a cheap anti-microbial agent that has had a very good effect on H pylori (In vitro and In vivo) and this anti-microbial agent may bean appropriate alternative for METRONIDAZOLe in eradication of H pylori in developing countries. In this randomized controlled study we compared the efficacy of 2 quadruple regimens containing FURAZOLIDONE vs METRONIDAZOLe for eradication of H pylori in Iranian PEPTIC ULCER disease patients. Patients and Methods: 200 adult patients with duodenal ulcer and H pylori infection randomly were assigned to take one of these following regimens: omeprazole 20 mg bid, tetracycline 500 rng tid, bismuth sub-citrate 240 mg bid and (metronidazole 500 mg tid Vs FURAZOLIDONE 100 mg tid) for 2 weeks. Side effects of drugs were evaluated on 2-week follow up. Rapid unease test and histology from antrum and corpus with special staining on 6-week follow-up determined H pylori eradication.Results: 181 patients (Male/Female: 109/82, 84 in METRONIDAZOLe and 97 in FURAZOLIDONE groups) completed the study. The most frequent drug side effects were bad taste (OTBM Vs OTBF: 51% Vs 16%, P: 0.000001), dry mouth (OTBM Vs OTBF: 30% Vs 16%, P: 0.01) and nausea (OTBM Vs OTBF: 31% Vs 23%, P: NS). Eradication of H.pylori was documented in 53/84 (63%) (Intention to treat: 53/100) and 75/97 (77%) (Intention to treat: 75/100) of OTBM and OTBF groups respectively (P: 0.027).Conclusion: Quadruple therapy using FURAZOLIDONE is more effective than METRONIDAZOLe for eradication of H pylori in Iranian patients but this regimen is not an ideal regimen yet and modification of this regimen may heighten its efficacy.

Cites

CIPROFLOXACIN VS. METRONIDAZOLE IN QUADRUPLE THERAPY REGIMENS FOR THE TREATMENT OF H .PYLORI INFECTION IN PATIENTS WITH DUODENAL ULCER

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APA: Copy

KAVIANI, M.J., SARI ASLANI, F., SABERI FIROUZI, M., BORD BAR, B., FATAHI, S.J., TABEEI, S.Z.A.D., & MASARAT, S.. (2001). TRIAL COMPARING METRONIDAZOLE AND FURAZOLIDONE (OMEPRAZOLE, TETRACYCLINE, BISMUTH PLUS METRONIDAZOLE VS FURAZOLIDONE) FOR ERADICATION OF HELICOBACTER PYLORI IN IRANIAN PEPTIC ULCER DISEASE PATIENTS. GOVARESH JOURNAL, 5(27-28), 75-80. SID. https://sid.ir/paper/86239/en

Vancouver: Copy

KAVIANI M.J., SARI ASLANI F., SABERI FIROUZI M., BORD BAR B., FATAHI S.J., TABEEI S.Z.A.D., MASARAT S.. TRIAL COMPARING METRONIDAZOLE AND FURAZOLIDONE (OMEPRAZOLE, TETRACYCLINE, BISMUTH PLUS METRONIDAZOLE VS FURAZOLIDONE) FOR ERADICATION OF HELICOBACTER PYLORI IN IRANIAN PEPTIC ULCER DISEASE PATIENTS. GOVARESH JOURNAL[Internet]. 2001;5(27-28):75-80. Available from: https://sid.ir/paper/86239/en

IEEE: Copy

M.J. KAVIANI, F. SARI ASLANI, M. SABERI FIROUZI, B. BORD BAR, S.J. FATAHI, S.Z.A.D. TABEEI, and S. MASARAT, “TRIAL COMPARING METRONIDAZOLE AND FURAZOLIDONE (OMEPRAZOLE, TETRACYCLINE, BISMUTH PLUS METRONIDAZOLE VS FURAZOLIDONE) FOR ERADICATION OF HELICOBACTER PYLORI IN IRANIAN PEPTIC ULCER DISEASE PATIENTS,” GOVARESH JOURNAL, vol. 5, no. 27-28, pp. 75–80, 2001, [Online]. Available: https://sid.ir/paper/86239/en

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