INVESTIGATION OF METHYLATION OF TNF-Α GENE PROMOTER IN PATIENTS WITH TYPE 2 DIABETES

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MORADI ZAHRA; Ravari Mehrnaz Sadat; FARROKHI EFFAT; HASHEMZADEH CHALESHTORI MORTEZA

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Journal Paper

Paper Information

Journal: Iranian Journal of Diabetes and Metabolism Year:2019 | Volume:19 | Issue:1 Page(s): 44-50

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Title

INVESTIGATION OF METHYLATION OF TNF-Α GENE PROMOTER IN PATIENTS WITH TYPE 2 DIABETES

Author(s)

MORADI ZAHRA | Ravari Mehrnaz Sadat | FARROKHI EFFAT | HASHEMZADEH CHALESHTORI MORTEZA | Issue Writer Certificate

Keywords

Type 2 diabetes mellitusQ1

EpigeneticQ2

TNF-αQ1

DNA methylationQ1

Abstract

Background: Type II diabetes is a chronic inflammatory condition that is associated with a combination of genetic and environmental factors. Tumor necrosis factor alpha or TNF-α as an adipocyte cytokine, which affects the signaling pathway of insulin, can contribute to insulin resistance in type 2 diabetes patients. Considering the importance of Epigenetic changes in multifactorial diseases, this study aimed to investigate TNF-α promoter methylation in patients with type 2 diabetes. Methods: This study was performed on 61 patients with type 2 diabetes and 31 non-diabetic patients. The Groups were matched in terms of demographic characteristics. The lipid profiles were measured by standard kits. TNF-α promoter methylation levels were measured by bisulphite treatment method, Nested PCR and sequencing. Results: There was no association between TNF-α promoter methylation gene promoter and type 2 diabetes in the studied groups. Also, there was no association between TNF-α promoter methylation in diabetic and non-diabetic groups between males and females. Conclusion: The Epigenetic changes in cytokines that contribute to insulin resistance in type 2 diabetic patients seem to be ineffective in peripheral blood samples, and other tissues may need to be investigated in this regard.

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APA: Copy

MORADI, ZAHRA, Ravari, Mehrnaz Sadat, FARROKHI, EFFAT, & HASHEMZADEH CHALESHTORI, MORTEZA. (2019). INVESTIGATION OF METHYLATION OF TNF-Α GENE PROMOTER IN PATIENTS WITH TYPE 2 DIABETES. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 19(1 ), 44-50. SID. https://sid.ir/paper/413537/en

Vancouver: Copy

MORADI ZAHRA, Ravari Mehrnaz Sadat, FARROKHI EFFAT, HASHEMZADEH CHALESHTORI MORTEZA. INVESTIGATION OF METHYLATION OF TNF-Α GENE PROMOTER IN PATIENTS WITH TYPE 2 DIABETES. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2019;19(1 ):44-50. Available from: https://sid.ir/paper/413537/en

IEEE: Copy

ZAHRA MORADI, Mehrnaz Sadat Ravari, EFFAT FARROKHI, and MORTEZA HASHEMZADEH CHALESHTORI, “INVESTIGATION OF METHYLATION OF TNF-Α GENE PROMOTER IN PATIENTS WITH TYPE 2 DIABETES,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 19, no. 1 , pp. 44–50, 2019, [Online]. Available: https://sid.ir/paper/413537/en

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