Comparative evaluation on the Effect of Phenytoin Ointment, Aloe Vera Gel, Royal Jelly and Honey on Wound Healing in the Animal Model of Rabbit: Histopathological and Macroscopic Evaluation

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Razavi Seyed Arman; BIGHAM SADEGH AMIN; KARIMI IRAJ; SHARIFI SIAVASH; Hafar Iman

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Journal: Journal of Sabzevar University of Medical Sciences Year:2021 | Volume:28 | Issue:3 Page(s): 387-395

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Title

Comparative evaluation on the Effect of Phenytoin Ointment, Aloe Vera Gel, Royal Jelly and Honey on Wound Healing in the Animal Model of Rabbit: Histopathological and Macroscopic Evaluation

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Keywords

PhenytoinQ2

Aloe vera gelQ1

Royal JellyQ2

HoneyQ2

Wound healingQ2

RabbitQ3

Abstract

Introduction: Phenytoin ointment is a usual medicine for Wound healing. Aloe vera gel promotes Wound healing by directly stimulating the activity of macrophages and fibroblasts that increase both collagen and proteoglycan synthesis, thereby promoting tissue repair. The aim of this study was to evaluate the effects of Phenytoin ointment1%, Aloe vera gel, Royal Jelly and Honey on skin Wound healing in Rabbit animal model. Materials and Methods: 5 Rabbits with 50 skin wounds were used in this study. Phenytoin ointment1%, Aloe vera gel, Royal Jelly and Honey were used in four wounds and another was considered as an untreated control. Macroscopic study was performed on days 4, 8, 12, 16 and 20 after wounding and histopathologic study was done on the days 10 and 21 from the wounds. Results: On the 8th and 12th days in the Aloe vera gel, Royal Jelly and Honey groups, the area of the wound had a significant difference (P<0. 05) than group1 (Phenytoin), indicating a faster reduction of the wound surface than the Phenytoin group. On the 16th day after surgery, the ulcer surface of the Honey group was completely closed and on day 20 all the wounds were fully restored in all groups. Also, histopathologic studies on 10 and 21 days showed no significant difference between the studied groups and all wounds were completely restored on day 20. Conclusion: Finally, the results of this Study showed that Phenytoin 1% ointment, Aloe vera gel, Royal Jelly and Honey, all had a good effect on Wound healing.

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APA: Copy

Razavi, Seyed Arman, BIGHAM SADEGH, AMIN, KARIMI, IRAJ, SHARIFI, SIAVASH, & Hafar, Iman. (2021). Comparative evaluation on the Effect of Phenytoin Ointment, Aloe Vera Gel, Royal Jelly and Honey on Wound Healing in the Animal Model of Rabbit: Histopathological and Macroscopic Evaluation. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 28(3 ), 387-395. SID. https://sid.ir/paper/413643/en

Vancouver: Copy

Razavi Seyed Arman, BIGHAM SADEGH AMIN, KARIMI IRAJ, SHARIFI SIAVASH, Hafar Iman. Comparative evaluation on the Effect of Phenytoin Ointment, Aloe Vera Gel, Royal Jelly and Honey on Wound Healing in the Animal Model of Rabbit: Histopathological and Macroscopic Evaluation. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2021;28(3 ):387-395. Available from: https://sid.ir/paper/413643/en

IEEE: Copy

Seyed Arman Razavi, AMIN BIGHAM SADEGH, IRAJ KARIMI, SIAVASH SHARIFI, and Iman Hafar, “Comparative evaluation on the Effect of Phenytoin Ointment, Aloe Vera Gel, Royal Jelly and Honey on Wound Healing in the Animal Model of Rabbit: Histopathological and Macroscopic Evaluation,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 3 , pp. 387–395, 2021, [Online]. Available: https://sid.ir/paper/413643/en

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