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Information Journal Paper

Title

DESIGN AND FABRICATION OF ELECTROCHEMICAL BIOSENSOR BASED ON NANO-GRAPHENE TO DETECT SEROTONIN IN DIABETIC ZEBRA FISH

Pages

  234-251

Abstract

 Background: A Novel Nanocomposite-modified electrode based on reduced graphene oxide (rGO) decorated with crown-ether and gold nanoparticles (GNPs) on the surface of a glassy carbon electrode (GCE) was fabricated to investigate 5-HT determination. Methods: The morphology of nanocomposite was characterized by scaning electron microscopy (SEM). Diabetic Zebrafish was obtained by overfeeding via glucose. 5-HT was successfully determined in the presence of dopamine (DA), ascorbic acid (AA), urea, glucose, and L-tryptophan (L-Trp) by using electrochemical methods. Results: The nanocomposite exhibited satisfactory electrochemical catalytic activity for 5-HT determination using square-wave voltammetry (SWV). The electrochemical behavior of 5-HT at the nanocomposite/GCE displayed reasonable oxidation current and potential. The limit of detection (LOD) of 5-HT obtained from the real samples, containing the control and diabetic group by using the proposed system and HPLC method, was calculated to be about 0. 3 and 0. 1 µ g/L, respectively. The prposed system also demonstrated high selectivity, reasonable sensitivity, and good stability and reproducibility for 5-HT sensing. The nanocomposite was applied for the determination of the Biomarker 5-HT in the diabetic and control groups of zebrafish and displayed excellent recoveries about 93 and low relative error about 3% while compared with standard method. Conclusions: It seems that the 5-HT level can be used for earlier diagnosis of diabetes.

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    Cite

    APA: Copy

    KHOSHNEVISAN, KAMYAR, FARIDBOD, FARNOUSH, LARIJANI, BAGHER, & KHORRAMIZADEH, MOHAMMAD REZA. (2020). DESIGN AND FABRICATION OF ELECTROCHEMICAL BIOSENSOR BASED ON NANO-GRAPHENE TO DETECT SEROTONIN IN DIABETIC ZEBRA FISH. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 19(5 ), 234-251. SID. https://sid.ir/paper/413954/en

    Vancouver: Copy

    KHOSHNEVISAN KAMYAR, FARIDBOD FARNOUSH, LARIJANI BAGHER, KHORRAMIZADEH MOHAMMAD REZA. DESIGN AND FABRICATION OF ELECTROCHEMICAL BIOSENSOR BASED ON NANO-GRAPHENE TO DETECT SEROTONIN IN DIABETIC ZEBRA FISH. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2020;19(5 ):234-251. Available from: https://sid.ir/paper/413954/en

    IEEE: Copy

    KAMYAR KHOSHNEVISAN, FARNOUSH FARIDBOD, BAGHER LARIJANI, and MOHAMMAD REZA KHORRAMIZADEH, “DESIGN AND FABRICATION OF ELECTROCHEMICAL BIOSENSOR BASED ON NANO-GRAPHENE TO DETECT SEROTONIN IN DIABETIC ZEBRA FISH,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 19, no. 5 , pp. 234–251, 2020, [Online]. Available: https://sid.ir/paper/413954/en

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