CORRELATION BETWEEN GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND
NEONATAL HYPERBILIRUBINEMIA

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ZAHED PASHA Y.A.; SAJADI S.A.

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Journal Paper

Paper Information

Journal: Journal of Medical Council of Iran Year:2002 | Volume:20 | Issue:3 Page(s): 171-175

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Information Journal Paper

Title

CORRELATION BETWEEN GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND NEONATAL HYPERBILIRUBINEMIA

Author(s)

ZAHED PASHA Y.A. | SAJADI S.A. | Issue Writer Certificate

Keywords

GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCYQ4

JAUNDICEQ3

NEONATEQ3

EXCHANGE TRANSFUSIONQ3

Abstract

G6PD deficiency is the most common enzyme deficiency in human beings-It can lead to severe hyperbilirubinemia which my progress to bilirubin encephalopathy, mental retardation and death in newborn infant.This cross sectional analysis was carried out in newborn services of Amirkola children hospital. In this study 165 icteric NEONATEs (cases) and 123 nonicteric NEONATEs were assessed. Enzyme activity were assesed by fluorescent spot test and the results were analysed by chi-square and fisher exact tests and a p value<0.05 was considered significant.G6PD deficiency was seen in 23.6% of the icteric and 11.6% of the nonicteric newborns (P <0.0001).36% of G6PD deficient and 18.2% of non-deficient NEONATEs required EXCHANGE TRANSFUSION (P<0.0010).In view of the higher frequency of G6PD deficiency and the greater need for EXCHANGE TRANSFUSION in these patients, we suggest G6PD screening on cord blood at birth for all NEONATEs, and G6PD level determination in all pathological JAUNDICE of newborn.

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