G6PDDDICIENCY AND ITS CONTRIBUTION TO NEONATAL JAUNDICE, AN EPIDEMIOLOGIC SURVEY IN 2000 NEWBORNS

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ABOU ALGHASEMI H.; MEHRANI H.; HOSSEINI SEYED MORTEZA; BADRI T.; KAVEHMANESH Z.; KHADEM ALHOSSEINI S.M.

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Journal: Journal of Medical Council of Iran Year:2003 | Volume:21 | Issue:2 Page(s): 93-100

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Title

G6PDDDICIENCY AND ITS CONTRIBUTION TO NEONATAL JAUNDICE, AN EPIDEMIOLOGIC SURVEY IN 2000 NEWBORNS

Author(s)

Keywords

G6PDQ3

NEONATAL JAUNDICEQ2

PHOTOTHERAPYQ3

SCREENING PROGRAMQ4

Abstract

Glucose-6-phosphate Dehydrogenase (G6PD) is one of the vital enzymes involved in the metabolism of red blood cells. The deficiency of this enzyme is one of the most common enzymatic deficiencies in human being. More than 400 variants of G6PD have been identified and 400 million people are suffering in the world. This condition can cause acute hemolysis during oxidative stress and also severe neonatal hyperbilirubinemia in some population. The objective of our study was to determine the prevalence of G6PD deficiency and its relation to NEONATAL JAUNDICE. Two thousand consecutively born babies at Najmieh and Baghiyatollah (a.s) hospitals (Tehran) from August 1999 up to February 2000 , were screened for G6PD deficiency. Blood samples were obtained from umbilical cord and tested by fluorescent sport test. These infants were observed for 10 days for development of jaundice.The results of the study are as follows: frequency of G6PD deficiency was 2.1% being 3.6% in males and 0.6% in females. Significant jaundice (Abdomen and soles) developed in 51.4% of infants having G6PD deficiency. versus 16.6% in normal infants (P= 0.000) . Mean +/-SD of bilirubin level in G6PD deficient and normal infant were, 18.76+/-56mg I dl and 15.5+/-4.2 mg/dl , respectively (P=0.000).Phototherapy was required in 48.6% of G6PD deficient infants and in 11.9% among normal infants (P=0.000) 11.4% of deficient, compared with 0.9% of normal infants, required exchange blood transfusion (P=0.000). Hemoglobin and reticulocyte values and hospitalization days in deficient and normal infants were not statistically different. Owing to the relatively high prevalence of G6PD deficiency and its relation to NEONATAL JAUNDICE and side effects related to it , a wide scale country wide population screening is strongly needed, so that on the one hand, neonates that are highly risk prone be taken care of under intensive 'coverage and their jaundice timely and speedily treated. On the other hand because of probable attacks of hemolysis due to fava bean consumption during childhood, and above that age, necessary warnings and adequate health education are imported.

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کمبود آنزیم گلوکز -6- فسفات دهیدروژناز و ارتباط آن با مالاریا

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APA: Copy

ABOU ALGHASEMI, H., MEHRANI, H., HOSSEINI, SEYED MORTEZA, BADRI, T., KAVEHMANESH, Z., & KHADEM ALHOSSEINI, S.M.. (2003). G6PDDDICIENCY AND ITS CONTRIBUTION TO NEONATAL JAUNDICE, AN EPIDEMIOLOGIC SURVEY IN 2000 NEWBORNS. JOURNAL OF MEDICAL COUNCIL OF I.R.I., 21(2), 93-100. SID. https://sid.ir/paper/41184/en

Vancouver: Copy

ABOU ALGHASEMI H., MEHRANI H., HOSSEINI SEYED MORTEZA, BADRI T., KAVEHMANESH Z., KHADEM ALHOSSEINI S.M.. G6PDDDICIENCY AND ITS CONTRIBUTION TO NEONATAL JAUNDICE, AN EPIDEMIOLOGIC SURVEY IN 2000 NEWBORNS. JOURNAL OF MEDICAL COUNCIL OF I.R.I.[Internet]. 2003;21(2):93-100. Available from: https://sid.ir/paper/41184/en

IEEE: Copy

H. ABOU ALGHASEMI, H. MEHRANI, SEYED MORTEZA HOSSEINI, T. BADRI, Z. KAVEHMANESH, and S.M. KHADEM ALHOSSEINI, “G6PDDDICIENCY AND ITS CONTRIBUTION TO NEONATAL JAUNDICE, AN EPIDEMIOLOGIC SURVEY IN 2000 NEWBORNS,” JOURNAL OF MEDICAL COUNCIL OF I.R.I., vol. 21, no. 2, pp. 93–100, 2003, [Online]. Available: https://sid.ir/paper/41184/en

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