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Information Journal Paper

Title

The Effect of Gallic Acid on Cognitive Dysfunctions with Intrauterine Growth Restriction in Rats

Pages

  185-199

Abstract

 Background: Intrauterine Growth Restriction (IUGR) lead to abnormalities in fetal central nervous system, till hippocampal and cortical cells became apoptotic. The goal of this research is investigating the effects of Gallic acid on improvement of cognitive impairments and nuclear factor kappa B (NFƙ B) in animal model of IUGR. Material and Methods: In this experimental study, 32 female Rats from wistar race with weighing approximately 180± 25g were divided into 4 groups of 7. Control group: that did not receive any treatment. IUGR group: To induce IUGR of pregnant Rats were under 50 % restricted diet from the 14 th day of pregnancy to childbirth. Experimental groups 1 and 2: pregnant Rats subjected to a 50 % dietary restriction for induction IUGR from 14 th day of pregnancy to childbirth and from 12 th day of pregnancy to the birth of newborns, received 200 and 400 mg/kg Gallic acid doses daily by gavage method. After the birth of pups, morphological evaluations were checked. Then, in 30 postnatal days working and passive avoidance tests and anxiety test were assessed. The serum level of NFƙ B was analyzed by ELISA. Results: The working memory and fear-based memory of IUGR Rats was reduced significantly compared to the controls. In addition restricted diet leads to increase in NFƙ B and anxiety levels. Gallic acid was amelioRated working and fear-based memories and reduced serum level of NFƙ B and anxiety in treated Rats. Conclusion: The findings suggest that restricted diet during pregnancy can cause behavioral Cognitive Disorders in Rats. This is likely due to increased levels of pro-apoptic cytokine such as NFƙ B. The results also suggest that the neuroprotective effect of Gallic acid is likely to improve memory disorders in IUGR Rat model.

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    APA: Copy

    Saberi, Zohreh, & EDALATMANESH, MOHAMMAD AMIN. (2019). The Effect of Gallic Acid on Cognitive Dysfunctions with Intrauterine Growth Restriction in Rats. ALBORZ UNIVERSITY MEDICAL JOURNAL, 8(2 ), 185-199. SID. https://sid.ir/paper/414641/en

    Vancouver: Copy

    Saberi Zohreh, EDALATMANESH MOHAMMAD AMIN. The Effect of Gallic Acid on Cognitive Dysfunctions with Intrauterine Growth Restriction in Rats. ALBORZ UNIVERSITY MEDICAL JOURNAL[Internet]. 2019;8(2 ):185-199. Available from: https://sid.ir/paper/414641/en

    IEEE: Copy

    Zohreh Saberi, and MOHAMMAD AMIN EDALATMANESH, “The Effect of Gallic Acid on Cognitive Dysfunctions with Intrauterine Growth Restriction in Rats,” ALBORZ UNIVERSITY MEDICAL JOURNAL, vol. 8, no. 2 , pp. 185–199, 2019, [Online]. Available: https://sid.ir/paper/414641/en

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