Antifungal susceptibility to azoles drugs in Candida species isolated from patients with onychomycosis

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LOTFALI ENSIEH; CHERAGHI ZAHRA; Farzaneh Yasamin; Dehbashi Zakieh; Dorrian Mahtab; Keymaram Mahyar; Fattahi Azam

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Journal: Dermatology and Cosmetics Year:2021 | Volume:12 | Issue:2 Page(s): 91-100

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Title

Antifungal susceptibility to azoles drugs in Candida species isolated from patients with onychomycosis

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Keywords

onychomycosisQ1

candida albicansQ1

candida glabrataQ1

antifungal susceptibility testQ1

Abstract

Background and Aim: onychomycosis is an infection caused by yeast, filamentous and non-filamentous fungi, due to diverse conditions. This study aimed to investigate the pattern of azole susceptibility of candidate species isolated from Iranian patients in Tehran. Methods: After sampling from patients, identification of the isolated strains were performed with Candida chrom agar medium and PCR-sequencing test. Drug Susceptibility pattern of the species to fluconazole, itraconazole and ketoconazole were determined by CLSI-M27-A3/S4 standard method. Results: In this study, 34 candidate isolates were identified, of which 26 isolates (76. 5%) were candida albicans and 8 isolates (23. 5%) were candida glabrata. In fluconazole, 4 (11%) of the isolates were dose-dependent sensitive and the others were sensitive. In itraconazole, 21 (61%) dosedependent isolates and 2 (5%) resistant isolates were identified, and in ketoconazole, all isolates were sensitive. The geometric mean (GM) of the minimum inhibitory concentration for fluconazole, itraconazole and ketoconazole was 0. 32, 0. 21 and 0. 15 μ g/mL, respectively. In this study, the most frequently isolated species was C. albicans. According to the GM values, the most effective azoles was ketoconazole. Conclusion: The prevalence and pattern of susceptibility of Candida species to azole may vary in different populations of patients. Therefore, it is recommended that the clinicians pay attention to the results of drug susceptibility tests and then treat patients by considering drug interactions and side effects.

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References

Molecular evaluation of candida species as etiologic agents of onychomycosis

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APA: Copy

LOTFALI, ENSIEH, CHERAGHI, ZAHRA, Farzaneh, Yasamin, Dehbashi, Zakieh, Dorrian, Mahtab, Keymaram, Mahyar, & Fattahi, Azam. (2021). Antifungal susceptibility to azoles drugs in Candida species isolated from patients with onychomycosis. DERMATOLOGY AND COSMETIC, 12(2 ), 91-100. SID. https://sid.ir/paper/414822/en

Vancouver: Copy

LOTFALI ENSIEH, CHERAGHI ZAHRA, Farzaneh Yasamin, Dehbashi Zakieh, Dorrian Mahtab, Keymaram Mahyar, Fattahi Azam. Antifungal susceptibility to azoles drugs in Candida species isolated from patients with onychomycosis. DERMATOLOGY AND COSMETIC[Internet]. 2021;12(2 ):91-100. Available from: https://sid.ir/paper/414822/en

IEEE: Copy

ENSIEH LOTFALI, ZAHRA CHERAGHI, Yasamin Farzaneh, Zakieh Dehbashi, Mahtab Dorrian, Mahyar Keymaram, and Azam Fattahi, “Antifungal susceptibility to azoles drugs in Candida species isolated from patients with onychomycosis,” DERMATOLOGY AND COSMETIC, vol. 12, no. 2 , pp. 91–100, 2021, [Online]. Available: https://sid.ir/paper/414822/en

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