THE PROBIOTIC EFFECTS OF LACTOBACILLUS CASEI IN BALB/C MICE ON THE TUMOR GROWTH RATE BEARING BREAST CANCER

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YAZDI M.H.; SOLTAN DALAL MOHAMMAD MAHDI; MOHAMMAD HASAN ZOHEYR; HOULAKOUEI MARZIEH; PEYMANEH ABEDI MOHTASAB TARANEH; AGHA AMIRI SOULMAZ; MAHDAVI M.; SEYED AMIRI SOUNIA

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Journal: Journal of Medical Council of Iran Year:2009 | Volume:27 | Issue:1 Page(s): 43-51

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Title

THE PROBIOTIC EFFECTS OF LACTOBACILLUS CASEI IN BALB/C MICE ON THE TUMOR GROWTH RATE BEARING BREAST CANCER

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Keywords

PROBIOTICQ2

LACTOBACILLUS CASEIQ2

TUMOR GROWTHQ3

BREAST CANCERQ3

Abstract

Background: Antitumor effect of lactic acid bacteria (LAB) have been shown in many studies, this effect maybe as a result of immunomodulatory properties of these bacteria. In present work we have studied the effect of LACTOBACILLUS CASEI on the TUMOR GROWTH rate in BALB/c mices bearing BREAST CANCER.Methods: 6-8 week-old In-bred BALB/c mice, each weighing 25–30 g, were used. There are two experimental group consisted of 9 mices that they were used as controls in each assay. The L.casei ATCC39392 strain used in this study was inoculated in MRS broth and cultivated for a day at 37 °C under anaerobic conditions, collected by centrifugation and resuspend in PBS. After preparation of proper amount of this suspension it was orally administered to the mice with a gastric feeding, Control mice received an equal volume of PBS in duration of study.Results: results of this study showed that oral administration of L.casei can inhibit the TUMOR GROWTH and increased the local inflammation in DTH assay as a result of increase in immune responses efficiency.Conclusion: In conclusion oral administration of LACTOBACILLUS CASEI may regulate immune responses skewed Th1 balance and maybe helpful for cancer immunotherapy, but further studies is needed to investigate the other mechanisms of this effect.

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APA: Copy

YAZDI, M.H., SOLTAN DALAL, MOHAMMAD MAHDI, MOHAMMAD HASAN, ZOHEYR, HOULAKOUEI, MARZIEH, PEYMANEH ABEDI MOHTASAB, TARANEH, AGHA AMIRI, SOULMAZ, MAHDAVI, M., & SEYED AMIRI, SOUNIA. (2009). THE PROBIOTIC EFFECTS OF LACTOBACILLUS CASEI IN BALB/C MICE ON THE TUMOR GROWTH RATE BEARING BREAST CANCER. JOURNAL OF MEDICAL COUNCIL OF I.R.I., 27(1), 43-51. SID. https://sid.ir/paper/41490/en

Vancouver: Copy

YAZDI M.H., SOLTAN DALAL MOHAMMAD MAHDI, MOHAMMAD HASAN ZOHEYR, HOULAKOUEI MARZIEH, PEYMANEH ABEDI MOHTASAB TARANEH, AGHA AMIRI SOULMAZ, MAHDAVI M., SEYED AMIRI SOUNIA. THE PROBIOTIC EFFECTS OF LACTOBACILLUS CASEI IN BALB/C MICE ON THE TUMOR GROWTH RATE BEARING BREAST CANCER. JOURNAL OF MEDICAL COUNCIL OF I.R.I.[Internet]. 2009;27(1):43-51. Available from: https://sid.ir/paper/41490/en

IEEE: Copy

M.H. YAZDI, MOHAMMAD MAHDI SOLTAN DALAL, ZOHEYR MOHAMMAD HASAN, MARZIEH HOULAKOUEI, TARANEH PEYMANEH ABEDI MOHTASAB, SOULMAZ AGHA AMIRI, M. MAHDAVI, and SOUNIA SEYED AMIRI, “THE PROBIOTIC EFFECTS OF LACTOBACILLUS CASEI IN BALB/C MICE ON THE TUMOR GROWTH RATE BEARING BREAST CANCER,” JOURNAL OF MEDICAL COUNCIL OF I.R.I., vol. 27, no. 1, pp. 43–51, 2009, [Online]. Available: https://sid.ir/paper/41490/en

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