Comparison of aqueous extract of Orchid's root (Dactylorhiza maculate) with ibuprofen on pain sensory thresholds using the formalin test in adult male rats

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KARGAR JAHROMI HOSSEIN; Solhjoo Esmaeil; Hasannezhad Arash; Pourahmadi Mohammad; SAHRAEI REZA; ATASHPOUR SHEKOUFEH

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Journal: Pars Journal of Medical Sciences Year:2020 | Volume:18 | Issue:1 Page(s): 15-22

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Title

Comparison of aqueous extract of Orchid's root (Dactylorhiza maculate) with ibuprofen on pain sensory thresholds using the formalin test in adult male rats

Author(s)

Keywords

OrchidQ1

PainQ2

FormalinQ3

RatQ2

Abstract

Introduction: Pain is an unpleasant feeling that usually occurs as a result of tissue injuries. Orchid could have significant analgesic effects in acute and chronic Pain modalities due to its glucomannan content. Considering the antioxidant and anti-inflammatory properties of the Orchid root’ s compounds, the aim of this study was to determine the effect of Orchid root extract on the reduction and prevention of Formalin-induced Pain. Materials and Methods: In this experimental study, 56 male Wistar Rats were randomly divided into 7 groups, including Control, Sham (distilled water), Ibuprofen (6 mg/kg) groups and four groups receiving the aqueous extract of Orchid root (80, 160, 320 and 640 mg/kg). All treatments were injected intra peritoneal. Formalin test was performed 30 minutes after injection of Orchid extract. Data were analyzed by one-way ANOVA and Duncan's post-test at a significance level of 0. 05. Results: Orchid at concentRations of 320 and 640 mg/kg caused a significant reduction in acute Pain and at concentRations of 160, 320 and 640 mg/kg significantly decreased chronic Pain. Ibuprofen also reduced acute and chronic Pain induced by Formalin. Conclusion: This research demonstRated the dose-dependent anti-nociceptive effect of Orchid root extract which is probably related to glucomannan and its antioxidant and anti-inflammatory properties.

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APA: Copy

KARGAR JAHROMI, HOSSEIN, Solhjoo, Esmaeil, Hasannezhad, Arash, Pourahmadi, Mohammad, SAHRAEI, REZA, & ATASHPOUR, SHEKOUFEH. (2020). Comparison of aqueous extract of Orchid's root (Dactylorhiza maculate) with ibuprofen on pain sensory thresholds using the formalin test in adult male rats. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), 18(1 ), 15-22. SID. https://sid.ir/paper/415187/en

Vancouver: Copy

KARGAR JAHROMI HOSSEIN, Solhjoo Esmaeil, Hasannezhad Arash, Pourahmadi Mohammad, SAHRAEI REZA, ATASHPOUR SHEKOUFEH. Comparison of aqueous extract of Orchid's root (Dactylorhiza maculate) with ibuprofen on pain sensory thresholds using the formalin test in adult male rats. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)[Internet]. 2020;18(1 ):15-22. Available from: https://sid.ir/paper/415187/en

IEEE: Copy

HOSSEIN KARGAR JAHROMI, Esmaeil Solhjoo, Arash Hasannezhad, Mohammad Pourahmadi, REZA SAHRAEI, and SHEKOUFEH ATASHPOUR, “Comparison of aqueous extract of Orchid's root (Dactylorhiza maculate) with ibuprofen on pain sensory thresholds using the formalin test in adult male rats,” PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), vol. 18, no. 1 , pp. 15–22, 2020, [Online]. Available: https://sid.ir/paper/415187/en

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