Evaluation of 45bp Ins/Del Genetic Variant in UCP-2 Gene as a Risk factor for Bipolar Disorder

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KOHAN L.; ZAREI F.; MOGHIMI E.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2021 | Volume:28 | Issue:6 Page(s): 62-69

Download Full-Text

Persian Verion

View:

320

Download:

Cites:

Information Journal Paper

Title

Evaluation of 45bp Ins/Del Genetic Variant in UCP-2 Gene as a Risk factor for Bipolar Disorder

Author(s)

KOHAN L. | ZAREI F. | MOGHIMI E. | Issue Writer Certificate

Keywords

Bipolar disorderQ1

Genetic variantQ1

MitochondriaQ1

UCP-2Q2

Abstract

Introduction: Bipolar disorder is a type biphasic disorder of energy availability that indicates increased Mitochondrial respiration in episodes of mania, compared to decreased Mitochondrial function in the depressive phase of the illness. Mitochondrial dysfunction may lead to an excessive increase in reactive oxygen species (ROS). The UCP-2 proteins act as regulators of ROS in the cell. This study aimed to investigate the association of UCP-2 45bp ins/del Genetic variant with susceptibility to Bipolar disorder. Materials & Methods: This case-control study was performed on 205 subjects with Bipolar disorder and 200 healthy subjects as a control group. After extraction of DNA from peripheral blood samples, genotype determination was performed using the PCR method. Moreover, the logistic regression analysis was used for the comparison of genotypes and allele frequencies between case and control groups. Findings: There was a significant association between ID (OR=0. 42; 95% CI= 0. 27-0. 64; P<0. 001) and II (OR=0. 39; 95% CI=0. 20-0. 77; P=0. 006) genotypes with Bipolar disorder. Data analysis showed I allele had a protective effect on susceptibility to Bipolar disorder (OR=0. 56; 95% CI=0. 42-0. 75; P<0. 001). Discussions & Conclusions: This study investigated, for the first time, the association between UCP-2 45bp ins/del Genetic variant and Bipolar disorder. The results showed UCP-2 45bp ins/del Genetic variant was associated with Bipolar disorder; however, more studies are required to be conducted in different ethnicities to confirm these results.

Cites

No record.

References

Cite

APA: Copy

KOHAN, L., ZAREI, F., & MOGHIMI, E.. (2021). Evaluation of 45bp Ins/Del Genetic Variant in UCP-2 Gene as a Risk factor for Bipolar Disorder. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 28(6 ), 62-69. SID. https://sid.ir/paper/415204/en

Vancouver: Copy

KOHAN L., ZAREI F., MOGHIMI E.. Evaluation of 45bp Ins/Del Genetic Variant in UCP-2 Gene as a Risk factor for Bipolar Disorder. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2021;28(6 ):62-69. Available from: https://sid.ir/paper/415204/en

IEEE: Copy

L. KOHAN, F. ZAREI, and E. MOGHIMI, “Evaluation of 45bp Ins/Del Genetic Variant in UCP-2 Gene as a Risk factor for Bipolar Disorder,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 6 , pp. 62–69, 2021, [Online]. Available: https://sid.ir/paper/415204/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops