Association of UCP2 45bp ins/del Gene Polymorphism with Idiopathic Male Infertility

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GHADERI A.; KOHAN L.; ANVAR Z.

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Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2019 | Volume:26 | Issue:5 Page(s): 189-195

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Title

Association of UCP2 45bp ins/del Gene Polymorphism with Idiopathic Male Infertility

Author(s)

GHADERI A. | KOHAN L. | ANVAR Z. | Issue Writer Certificate

Keywords

IdiopathicQ1

Male infertilityQ2

UCP2Q1

PolymorphismQ1

Abstract

Introduction: Infertility is a reproductive issue that has influenced couples worldwide and caused them psychiatric and emotional troubles. It is believed that mitochondrial proteins play a major role in Male infertility. One of the most important of these proteins is UCP2, which consists of more than 10% of mitochondria’ s inner membrane proteins. The purpose of this study was to investigate the association of UCP2 45bp ins/del Polymorphism with Idiopathic Male infertility. Materials & Methods: In this case-control study, UCP2 Polymorphism was investigated in 196 individuals with Idiopathic infertility and 278 healthy individuals. UCP2 45bp ins/del genotypes were identified by the polymerase chain reaction (PCR) technique. Also, genotype and allele frequencies in cases and controls were assessed by logistic regression analysis. Findings: No association was observed between UCP2 45bp ins/del Polymorphism genotypes and risk of Idiopathic Male infertility, but there was a marginal difference between cases and controls regarding II genotype frequency (P=0. 08). Moreover, data analysis showed that I allele had protective effect against Idiopathic Male infertility (OR: 0. 729, 95%CI: 0. 54-0. 985, P=0. 039). Discussion & Conclusions: In this study, for the first time, we found that the I allele in UCP2 45bp ins/del Polymorphism has protective effects against Idiopathic Male infertility. Further studies with larger sample sizes and different ethnicities are needed to confirm these results.

Cites

Evaluation of 45bp Ins/Del Genetic Variant in UCP-2 Gene as a Risk factor for Bipolar Disorder

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APA: Copy

GHADERI, A., KOHAN, L., & ANVAR, Z.. (2019). Association of UCP2 45bp ins/del Gene Polymorphism with Idiopathic Male Infertility. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 26(5 ), 189-195. SID. https://sid.ir/paper/89820/en

Vancouver: Copy

GHADERI A., KOHAN L., ANVAR Z.. Association of UCP2 45bp ins/del Gene Polymorphism with Idiopathic Male Infertility. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;26(5 ):189-195. Available from: https://sid.ir/paper/89820/en

IEEE: Copy

A. GHADERI, L. KOHAN, and Z. ANVAR, “Association of UCP2 45bp ins/del Gene Polymorphism with Idiopathic Male Infertility,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 5 , pp. 189–195, 2019, [Online]. Available: https://sid.ir/paper/89820/en

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