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Information Journal Paper

Title

Evaluation of the effect of manganese oxide nanoparticles on Toxoplasma gondii in vitro

Pages

  6-13

Abstract

 Introduction: Pyrimethamine and sulfadiazine are selective medications for toxoplasmosis, but some side effects hinder their consumption. Increasing the use of nanoparticles in biological studies and showing the benefi cial effects of manganese nanoparticles on fungi and bacteria, as well as the lack of suffi cient knowledge on its anti-Toxoplasma im-pacts, was the motivation for the design of this study. Manganese can provoke cell apoptosis by increasing the activation of the FRXO 3 a-Bim/ PUMA mRNA and caspase-3 pathway. The objective of this study was to investigate the effi cacy of manganese oxide nanoparticles (Mn 2 O 3 NPs) against Toxoplasma gondii (T. gondii) In vitro. Methods: To assess the anti-Toxoplasma activity of Mn2O3 NPs, the light microscopic observation was applied to evaluate the number of residual parasites in each well. Then, the MTT method was used to specify the toxic effect of Mn 2 O 3 NPs on T. gondii toxicity. Finally, the potential apoptosis of T. gondii by Mn2O3 NPs was investigated by fl ow cytometry assay Results: The IC50 value of Mn 2 O 3 NPs against T. gondii tachyzoite was 105 μ g/ml. There was also no signifi cant toxic effect of Mn 2 O 3 NPs on macrophages due to the high percentage of surviving macrophages at the desired concentration for treatment. The fi ndings of the fl ow cytometry revealed that about 40% of tachyzoites were caused to apoptosis with Mn 2 O 3 NPs. Conclusion: Mn 2 O 3 NPs have a benefi cial effect on T. gondii tachyzoite In vitro and could be regarded as a candidate for the treatment of this infection.

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    APA: Copy

    Tavakoli, Pooya, KarimiPour Saryazdi, Amir, DALIR GHAFFARI, ALI, BARATI, MOHAMMAD, & KarimiPour Saryazdi, Yeganeh. (2021). Evaluation of the effect of manganese oxide nanoparticles on Toxoplasma gondii in vitro. JOURNAL OF NURSE AND PHYSICIAN WITHIN WAR, 8(29 ), 6-13. SID. https://sid.ir/paper/415821/en

    Vancouver: Copy

    Tavakoli Pooya, KarimiPour Saryazdi Amir, DALIR GHAFFARI ALI, BARATI MOHAMMAD, KarimiPour Saryazdi Yeganeh. Evaluation of the effect of manganese oxide nanoparticles on Toxoplasma gondii in vitro. JOURNAL OF NURSE AND PHYSICIAN WITHIN WAR[Internet]. 2021;8(29 ):6-13. Available from: https://sid.ir/paper/415821/en

    IEEE: Copy

    Pooya Tavakoli, Amir KarimiPour Saryazdi, ALI DALIR GHAFFARI, MOHAMMAD BARATI, and Yeganeh KarimiPour Saryazdi, “Evaluation of the effect of manganese oxide nanoparticles on Toxoplasma gondii in vitro,” JOURNAL OF NURSE AND PHYSICIAN WITHIN WAR, vol. 8, no. 29 , pp. 6–13, 2021, [Online]. Available: https://sid.ir/paper/415821/en

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