PTEN POLYMORPHISM (IVS4) IN BREAST CANCER IN IRANIAN WOMEN

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MOFID B.; ESHRAGHI P.; DANESHPOUR M.A.S.; HEDAYATI MAHDI

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Journal: Research in Medicine Year:2009 | Volume:33 | Issue:3 Page(s): 179-182

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Information Journal Paper

Title

PTEN POLYMORPHISM (IVS4) IN BREAST CANCER IN IRANIAN WOMEN

Author(s)

MOFID B. | ESHRAGHI P. | DANESHPOUR M.A.S. | HEDAYATI MAHDI | Issue Writer Certificate

Keywords

PTENQ2

IVS4Q3

BREAST CANCERQ3

POLYMORPHISMQ3

Abstract

Background: Inactivation of tumor suppressor genes can cause irreversible uncontrolled growth. PTEN is a tumor suppressor gene and its POLYMORPHISM (IVS4) role in BREAST CANCER was investigated in this study.Methods: Forty-nine female subjects with confirmed BREAST CANCER comprised the case group and 43 healthy women participated as a control group in this study. The PTEN POLYMORPHISM was Genotyped by amplification of genomic DNA and then digestion by restriction of end nuclease and finally RFLP analysis.Results: The frequencies of mutant allele (M) were 0.37 and 0.27, respectively in the case and control groups. The genotype frequency distributions were in Hardy-Weinberg equilibrium in both groups.Conclusion: The mutant allele frequency in case group was 10%higherthan control group; it is possible that PTENIVS4 POLYMORPHISM has a role in BREAST CANCER.

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APA: Copy

MOFID, B., ESHRAGHI, P., DANESHPOUR, M.A.S., & HEDAYATI, MAHDI. (2009). PTEN POLYMORPHISM (IVS4) IN BREAST CANCER IN IRANIAN WOMEN. PAJOUHESH DAR PEZESHKI, 33(3), 179-182. SID. https://sid.ir/paper/41648/en

Vancouver: Copy

MOFID B., ESHRAGHI P., DANESHPOUR M.A.S., HEDAYATI MAHDI. PTEN POLYMORPHISM (IVS4) IN BREAST CANCER IN IRANIAN WOMEN. PAJOUHESH DAR PEZESHKI[Internet]. 2009;33(3):179-182. Available from: https://sid.ir/paper/41648/en

IEEE: Copy

B. MOFID, P. ESHRAGHI, M.A.S. DANESHPOUR, and MAHDI HEDAYATI, “PTEN POLYMORPHISM (IVS4) IN BREAST CANCER IN IRANIAN WOMEN,” PAJOUHESH DAR PEZESHKI, vol. 33, no. 3, pp. 179–182, 2009, [Online]. Available: https://sid.ir/paper/41648/en

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