The effect of resistance training with mesenchymal stem cell injection on TNF-α and kappa B nuclear factor levels in the cortex of streptozotocininduced diabetic rats

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Mohammadnezhad Behrooz; Hashemvarzi Seyed Abdollah; FARZANEH HESARI AMIN

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Journal: Journal of Jiroft University of Medical Sciences Year:2020 | Volume:7 | Issue:3 Page(s): 414-421

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Title

The effect of resistance training with mesenchymal stem cell injection on TNF-α and kappa B nuclear factor levels in the cortex of streptozotocininduced diabetic rats

Author(s)

Mohammadnezhad Behrooz | Hashemvarzi Seyed Abdollah | FARZANEH HESARI AMIN | Issue Writer Certificate

Keywords

Resistance training

Adipose-derived stem cells

Nuclear factor kappa B

Diabetes

Cortex

Abstract

Introduction: Neuropathy is the most common neurological complication of Diabetes which affects the central nervous systems, especially the brain. The aim of this study was to investigate the effects of Resistance training After Transplantation of stem cells on rate of TNF-α and NF-κ B in cerebral Cortex of STZ-induced Diabetic Rats. Materials and Methods: : In this experimental study, 48 male wistar rats, 9 weeks old, weighing 220-240 g were randomly divided into six equal groups: control, sham, Diabetes, Diabetes + exercise, Diabetes + stem cells, Diabetes + exercise + stem cells. The exercise groups, practiced treadmill Resistance training for 6 weeks. In the stem cell receiver group, 1/5*10 6 number of stem cells were injected into diabetic rats. Diabetes was induced by injection of streptozotocin (60 mg/kg) intraperitoneally. All statistical analyzes were performed by SPSS 22 software. Results: Data showed that the TNF-α (p>0. 01) and NF-κ B (p<0. 001) levels was significant difference between the six groups. It was observed that in the exercise + stem cells group, TNF-α level was significantly lower than that of the Diabetes group (p=0. 05). There was a statistically significant decrease in NF-κ B level in exercise and exercise + stem cells groups compared to the Diabetes group (p<0. 001). Conclusion: Injection of Adipose-derived stem cells along with exercise training can be a protective and therapeutic strategy to reduce cortical inflammatory markers and the effects of Diabetes on the central nervous system.

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References

Effect of exercise on type 2 diabetes-associated cognitive impairment in rats

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APA: Copy

Mohammadnezhad, Behrooz, Hashemvarzi, Seyed Abdollah, & FARZANEH HESARI, AMIN. (2020). The effect of resistance training with mesenchymal stem cell injection on TNF-α and kappa B nuclear factor levels in the cortex of streptozotocininduced diabetic rats. JOURNAL OF JIROFT UNIVERSITY OF MEDICAL SCIENCES, 7(3 ), 414-421. SID. https://sid.ir/paper/416524/en

Vancouver: Copy

Mohammadnezhad Behrooz, Hashemvarzi Seyed Abdollah, FARZANEH HESARI AMIN. The effect of resistance training with mesenchymal stem cell injection on TNF-α and kappa B nuclear factor levels in the cortex of streptozotocininduced diabetic rats. JOURNAL OF JIROFT UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;7(3 ):414-421. Available from: https://sid.ir/paper/416524/en

IEEE: Copy

Behrooz Mohammadnezhad, Seyed Abdollah Hashemvarzi, and AMIN FARZANEH HESARI, “The effect of resistance training with mesenchymal stem cell injection on TNF-α and kappa B nuclear factor levels in the cortex of streptozotocininduced diabetic rats,” JOURNAL OF JIROFT UNIVERSITY OF MEDICAL SCIENCES, vol. 7, no. 3 , pp. 414–421, 2020, [Online]. Available: https://sid.ir/paper/416524/en

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