ASSESSMENT OF IMMUNOGENIC LINEAR EPITOPES ON HUMAN IMMUNOGLOBULIN G BY IMMUNOINFORMATIC APPROACH

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HAJIGHASEMI FATEMEH; ROHANI SOHEILA; SEFID FATEMEH

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Journal: Research in Medicine Year:2016 | Volume:40 | Issue:1 Page(s): 30-35

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Title

ASSESSMENT OF IMMUNOGENIC LINEAR EPITOPES ON HUMAN IMMUNOGLOBULIN G BY IMMUNOINFORMATIC APPROACH

Author(s)

HAJIGHASEMI FATEMEH | ROHANI SOHEILA | SEFID FATEMEH | Issue Writer Certificate

Keywords

HUMAN IGGQ2

IMMUNOINFORMATICQ1

LINEAR EPITOPEQ1

Abstract

Background: Immunoglobulin G (IgG) is the most abundant antibody in serum. The amount of serum IgG is associated to severity of some diseases like immunodeficiencies and infections. Therefore, IgG has high diagnostic value. For precise measurement of IgG, diagnostic tools such as IgG-epitope specific monoclonal antibodies are needed.Immunoinformatic is a branch of immunology helps in more exact diagnosis of diseases using the computational biology. According to the significance of assessment of IgG level in some diseases such as immunodeficiency and infections and also efficacy of IMMUNOINFORMATIC methods for epitope mapping to develop monoclonal antibodies for diagnostic tests, this study was conducted for epitope mapping of HUMAN IGG by IMMUNOINFORMATIC.Methods of study: In this descriptive study, the amino acid sequence and third structure of reference HUMAN IGG was found in PDB database. The second IgG structure was determined by Phyre 2 software and the IgG LINEAR EPITOPEs were determined by Ellipro and IEDB IMMUNOINFORMATIC softwares.Results: LINEAR EPITOPEs were located in 160-175 and in 350- 360 amino acid sequences of light and heavy chains respectively as was determined by IEDB software. Eleven LINEAR EPITOPEs were located to constant domains of HUMAN IGG, one in constant domain 1 (CH1) and others in constant domains 2 and 3 (CH2 and CH3) of IgG heavy chain as were determined by Ellipro.5 Main epitopes are located in CH3 domain.Conclusion: In this study a lot of LINEAR EPITOPEs located on HUMAN IGG were determined by two IMMUNOINFORMATIC softwares. These epitopes are useful tools for producing specific monoclonal anti-IgG antibodies, epitope mapping of IgG, production of specific diagnostic tools for HUMAN IGG and phylogenic studies. It seems that IMMUNOINFORMATIC is a useful tool for mapping of LINEAR EPITOPEs of HUMAN IGG. Experimental studies would be valuable for confirming the IMMUNOINFORMATIC results in epitope mapping of HUMAN IGG.

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APA: Copy

HAJIGHASEMI, FATEMEH, ROHANI, SOHEILA, & SEFID, FATEMEH. (2016). ASSESSMENT OF IMMUNOGENIC LINEAR EPITOPES ON HUMAN IMMUNOGLOBULIN G BY IMMUNOINFORMATIC APPROACH. PAJOUHESH DAR PEZESHKI, 40(1 ), 30-35. SID. https://sid.ir/paper/41811/en

Vancouver: Copy

HAJIGHASEMI FATEMEH, ROHANI SOHEILA, SEFID FATEMEH. ASSESSMENT OF IMMUNOGENIC LINEAR EPITOPES ON HUMAN IMMUNOGLOBULIN G BY IMMUNOINFORMATIC APPROACH. PAJOUHESH DAR PEZESHKI[Internet]. 2016;40(1 ):30-35. Available from: https://sid.ir/paper/41811/en

IEEE: Copy

FATEMEH HAJIGHASEMI, SOHEILA ROHANI, and FATEMEH SEFID, “ASSESSMENT OF IMMUNOGENIC LINEAR EPITOPES ON HUMAN IMMUNOGLOBULIN G BY IMMUNOINFORMATIC APPROACH,” PAJOUHESH DAR PEZESHKI, vol. 40, no. 1 , pp. 30–35, 2016, [Online]. Available: https://sid.ir/paper/41811/en

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