EFFECTS OF L-CARNITINE SUPPLEMENTS ON INFLAMMATORY CYTOKINES, CRP AND OXIDATIVE STRESS IN HEMODIALYSIS PATIENTS

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SHAKERI AZAM; TABIBI H.; NOUBAKHT HAGHIGHI A.; HEDAYATI S.M.; CHAMARI M.

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Journal: Research in Medicine Year:2007 | Volume:31 | Issue:2 Page(s): 109-116

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Title

EFFECTS OF L-CARNITINE SUPPLEMENTS ON INFLAMMATORY CYTOKINES, CRP AND OXIDATIVE STRESS IN HEMODIALYSIS PATIENTS

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Keywords

L-CARNITINEQ3

HEMODIALYSISQ3

INFLAMMATIONQ2

OXIDATIVE STRESSQ2

Abstract

Background: INFLAMMATION and OXIDATIVE STRESS are common in patients with chronic renal disease, including HEMODIALYSIS patients. The present study was designed to investigate the effects of L-CARNITINE supplements on inflammatory cytokines, CRP and OXIDATIVE STRESS in HEMODIALYSIS patients.Materials and methods: The study was a randomized clinical trial. Thirty-six HEMODIALYSIS patients, (23 males and 13 females), were randomly assigned to either carnitine group or the control group. The patients in the carnitine group received 1000 mg/d oral L-CARNITINE for 12 weeks while the control group did not receive any L-CARNITINE supplement during the study. At the baseline and the end of 12th week of the study, 5 ml. blood was collected after a 12 to 14-hour fast from each patient before dialysis and then serum free carnitine, CRP, IL-1b, IL-6, TNF-a and ox-LDL were measured.Results: Mean serum free carnitine concentration increased significantly, by 86%, in the carnitine group at the end of 12th week as compared to the baseline (P<0.001), while serum CRP and IL-6 decreased significantly, by 29% (P<0.05) and 61% (P<0.001), respectively. No significant changes were observed in the serum concentrations of free carnitine, CRP and IL-6 in the control group during the study. There were no significant differences between mean changes of serum IL-1b, TNF-a and ox-LDL concentrations in the two groups.Conclusion: This study indicated that L-CARNITINE supplement could improve carnitine deficiency and decrease inflammatory markers of CRP and IL-6 in HEMODIALYSIS patients.

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APA: Copy

SHAKERI, AZAM, TABIBI, H., NOUBAKHT HAGHIGHI, A., HEDAYATI, S.M., & CHAMARI, M.. (2007). EFFECTS OF L-CARNITINE SUPPLEMENTS ON INFLAMMATORY CYTOKINES, CRP AND OXIDATIVE STRESS IN HEMODIALYSIS PATIENTS. PAJOUHESH DAR PEZESHKI, 31(2), 109-116. SID. https://sid.ir/paper/41846/en

Vancouver: Copy

SHAKERI AZAM, TABIBI H., NOUBAKHT HAGHIGHI A., HEDAYATI S.M., CHAMARI M.. EFFECTS OF L-CARNITINE SUPPLEMENTS ON INFLAMMATORY CYTOKINES, CRP AND OXIDATIVE STRESS IN HEMODIALYSIS PATIENTS. PAJOUHESH DAR PEZESHKI[Internet]. 2007;31(2):109-116. Available from: https://sid.ir/paper/41846/en

IEEE: Copy

AZAM SHAKERI, H. TABIBI, A. NOUBAKHT HAGHIGHI, S.M. HEDAYATI, and M. CHAMARI, “EFFECTS OF L-CARNITINE SUPPLEMENTS ON INFLAMMATORY CYTOKINES, CRP AND OXIDATIVE STRESS IN HEMODIALYSIS PATIENTS,” PAJOUHESH DAR PEZESHKI, vol. 31, no. 2, pp. 109–116, 2007, [Online]. Available: https://sid.ir/paper/41846/en

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