EFFECTS OF L-CARNITINE SUPPLEMENT ON SERUM AMYLOID A AND VASCULAR INFLAMMATORY FACTORS IN HEMODIALYSIS PATIENTS

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HAKESHZADEH F.; TABIBI H.; HEDAYATI MAHDI; MALAKOUTIAN T.

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Journal: JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY Year:2008 | Volume:3 | Issue:3 (10) Page(s): 33-43

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Title

EFFECTS OF L-CARNITINE SUPPLEMENT ON SERUM AMYLOID A AND VASCULAR INFLAMMATORY FACTORS IN HEMODIALYSIS PATIENTS

Author(s)

HAKESHZADEH F. | TABIBI H. | HEDAYATI MAHDI | MALAKOUTIAN T. | Issue Writer Certificate

Keywords

L-CARNITINEQ4

HEMODIALYSISQ4

SERUM AMYLOID AQ4

VASCULAR INFLAMMATIONQ4

Abstract

Background and objectives: Cardiovascular diseases are the most important cause of death in patients with chronic renal failure, including HEMODIALYSIS patients. Systemic inflammatory factors, including SERUM AMYLOID A and vascular inflammatory factors, are two major risk factors for atherosclerosis in these patients. The present study was designed to investigate the effects of L-CARNITINE supplement on SERUM AMYLOID A and vascular inflammatory factors in HEMODIALYSIS patients. Materials and methods: The study was a double-blind randomized clinical trial. Fourty-two HEMODIALYSIS patients (25 females and 17 males) were randomly assigned to either carnitine or a placebo group. The patients in the carnitine group received a vial containing 1000 mg oral L-CARNITINE daily for 12 weeks, while the placebo group received a corresponding placebo vial. At the baseline and the end of the 12th week of the study, 5 ml blood was collected from each patient and each control individual after a 12- to 14-hour fast before dialysis and SERUM AMYLOID A, free carnitine, sICAM-1, sICAM-2, sVCAM-1, sE-selectin, sP-selectin and ox-LDL levels were measured. Results: The mean serum free carnitine concentration increased by 150% in the carnitine group at the end of the 12th week as compared to the baseline value (P<0.001), while the SERUM AMYLOID A level decreased by 32% (P<0.001). No significant changes were observed in the serum concentrations of free carnitine or SERUM AMYLOID A in the control group. In addition, no significant differences were observed between the two groups in the mean changes of serum sICAM-1, sICAM-2, sVCAM-1, sE-selectin, sP-selectin or ox-LDL concentrations. Conclusion: The results of the present study indicate that L-CARNITINE supplement can reduce SERUM AMYLOID A concentration, as a systemic inflammatory indicator, in HEMODIALYSIS patients and may play an effective role in preventing cardiovascular diseases in these patients, while it has no effect on the serum vascular inflammatory factors.

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APA: Copy

HAKESHZADEH, F., TABIBI, H., HEDAYATI, MAHDI, & MALAKOUTIAN, T.. (2008). EFFECTS OF L-CARNITINE SUPPLEMENT ON SERUM AMYLOID A AND VASCULAR INFLAMMATORY FACTORS IN HEMODIALYSIS PATIENTS. JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY, 3(3 (10)), 33-43. SID. https://sid.ir/paper/121408/en

Vancouver: Copy

HAKESHZADEH F., TABIBI H., HEDAYATI MAHDI, MALAKOUTIAN T.. EFFECTS OF L-CARNITINE SUPPLEMENT ON SERUM AMYLOID A AND VASCULAR INFLAMMATORY FACTORS IN HEMODIALYSIS PATIENTS. JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY[Internet]. 2008;3(3 (10)):33-43. Available from: https://sid.ir/paper/121408/en

IEEE: Copy

F. HAKESHZADEH, H. TABIBI, MAHDI HEDAYATI, and T. MALAKOUTIAN, “EFFECTS OF L-CARNITINE SUPPLEMENT ON SERUM AMYLOID A AND VASCULAR INFLAMMATORY FACTORS IN HEMODIALYSIS PATIENTS,” JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY, vol. 3, no. 3 (10), pp. 33–43, 2008, [Online]. Available: https://sid.ir/paper/121408/en

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