EFFECTS OF PEGYLATED SILVER NANOPARTICLES ON THE STRUCTURE, FUNCTION, AND CONCENTRATIONS OF DIFFERENT FORMS OF HEMOGLOBIN

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ZOLGHADRI JAHROMI SAMANEH; SABOURY ALI AKBAR

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Journal: Research in Medicine Year:2018 | Volume:42 | Issue:2 Page(s): 79-85

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Title

EFFECTS OF PEGYLATED SILVER NANOPARTICLES ON THE STRUCTURE, FUNCTION, AND CONCENTRATIONS OF DIFFERENT FORMS OF HEMOGLOBIN

Author(s)

ZOLGHADRI JAHROMI SAMANEH | SABOURY ALI AKBAR | Issue Writer Certificate

Keywords

SILVER NANOPARTICLEQ1

HEMOGLOBINQ3

INTERACTIONQ1

Abstract

Background: The material is always covered by proteins immediately upon contact with a physiological environment. HEMOGLOBIN (Hb) is one of the major blood proteins. Due to the entry of substances into blood, HEMOGLOBIN may interact with them. The INTERACTION between HEMOGLOBIN and ligands such as nanoparticles is very important and may cause structural and functional changes on HEMOGLOBIN. According to the recent studies, PEG (poly ethylene glycol) coated nanoparticles have better biocompatibility compared with noncoated nanoparticles, thus the present study was conducted to investigate the INTERACTION of PEG-SILVER NANOPARTICLEs with HEMOGLOBIN.Materials and Methods: In the present experimental study, various spectroscopic methods, including UV Visible, fluorescence, and Circular Dichroism (CD), were used to evaluate the INTERACTION of SILVER NANOPARTICLEs with polyethylene glycol coating and HEMOGLOBIN. Using these methods, the effects of nanoparticles on the second structure and variations in the alpha helix and beta sheets of the protein, as well as changes in the third structure, and thus the change in the pr otein function, were investigated.Results: The results of fluorescence spectroscopy and UV/Vis absorption spectroscopy indicated that the structure of the Trp residue environments was altered and the physiological functions of Hb were affected by SILVER NANOPARTICLEs coated with poly ethylene glycol. It could also be suggested that due to the binding of SILVER NANOPARTICLE to Hb, some conformational changes are induced, enhancing the hydrophobicity.These nanoparticles have increased the ratio of deoxy and decreased HEMOGLOBIN tendency to oxygen. This increase in the highest concentration of nanoparticles is six times as common.Conclusion: The results showed that PEGylated SILVER NANOPARTICLEs lead to secondary structural changes and HEMOGLOBIN unfolding. Therefore, PEGylated SILVER NANOPARTICLEs decrease the HEMOGLOBIN function by decreasing the HEMOGLOBIN tendency toward oxygen. As a result, SILVER NANOPARTICLEs may cause the molecular toxicity of proteins. Considering the results obtained and the importance of nanoparticles biosafety, it is suggested that by changing the coating, size, or shape of nanoparticles and optimizing them, the possible side effects of nanoparticles on the structur e and function of the protein can be prevented.

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APA: Copy

ZOLGHADRI JAHROMI, SAMANEH, & SABOURY, ALI AKBAR. (2018). EFFECTS OF PEGYLATED SILVER NANOPARTICLES ON THE STRUCTURE, FUNCTION, AND CONCENTRATIONS OF DIFFERENT FORMS OF HEMOGLOBIN. PAJOUHESH DAR PEZESHKI, 42(2 ), 79-85. SID. https://sid.ir/paper/41975/en

Vancouver: Copy

ZOLGHADRI JAHROMI SAMANEH, SABOURY ALI AKBAR. EFFECTS OF PEGYLATED SILVER NANOPARTICLES ON THE STRUCTURE, FUNCTION, AND CONCENTRATIONS OF DIFFERENT FORMS OF HEMOGLOBIN. PAJOUHESH DAR PEZESHKI[Internet]. 2018;42(2 ):79-85. Available from: https://sid.ir/paper/41975/en

IEEE: Copy

SAMANEH ZOLGHADRI JAHROMI, and ALI AKBAR SABOURY, “EFFECTS OF PEGYLATED SILVER NANOPARTICLES ON THE STRUCTURE, FUNCTION, AND CONCENTRATIONS OF DIFFERENT FORMS OF HEMOGLOBIN,” PAJOUHESH DAR PEZESHKI, vol. 42, no. 2 , pp. 79–85, 2018, [Online]. Available: https://sid.ir/paper/41975/en

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