EVALUATION OF CD4+CD25+FOXP3+REGULATORY T-CELLS INCREASE IN TUMOR ENVIRONMENT OF INVASIVE INTRADUCTAL BREASTCARCINOMA AND CONTROL GROUP

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OFOGHI MAHYA; MESDAGHI MEHRNAZ; KHALILNEZHAD AHAD; TAHERIPANAH ROBABEH; AMANI DAVAR

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Journal: Research in Medicine Year:2015 | Volume:39 | Issue:2 Page(s): 55-59

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Title

EVALUATION OF CD4+CD25+FOXP3+REGULATORY T-CELLS INCREASE IN TUMOR ENVIRONMENT OF INVASIVE INTRADUCTAL BREASTCARCINOMA AND CONTROL GROUP

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Keywords

FLOW CYTOMETRYQ2

INVASIVE INTRADUCTAL BREAST CARCINOMAQ3

REGULATORY T-CELLSQ3

Abstract

Background: It seems that the population of REGULATORY T-CELLS increases in many malignancies leading to suppression of effector immune responses and thereby leads to progression of the disease. We aimed to assess infiltration of the REGULATORY T-CELLS into tumor environment in women with breast carcinoma.Methods: In a control-case study, 9 malignant tumor tissues from INVASIVE INTRADUCTAL BREAST CARCINOMA (case) and 8 benign breast tissues from healthy women (control) were mechanically and enzymatically processed. The prepared cell suspension was then subjected to staining of cell surface markers CD4 and CD25, and the extracellular marker FOXP3, and was finally analyzed by FLOW CYTOMETRY.Results: Population of REGULATORY T-CELLS in malignant tumor tissues showed significant increase compared to the control (p<0.001). A weak positive correlation was observed between size of the tumors and the infiltration of REGULATORY T-CELLS. Also, there was a moderate negative correlation between age of individuals and the number of REGULATORY T-CELLS in both malignant and benign breast tissues.Conclusions: Increased REGULATORY T-CELLS population in invasive intraductal breast tumor environment may be the major cause of immunosuppression contributing to the tumor progression. However, further studies with larger sample size are suggested to clarify this hypothesis.

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APA: Copy

OFOGHI, MAHYA, MESDAGHI, MEHRNAZ, KHALILNEZHAD, AHAD, TAHERIPANAH, ROBABEH, & AMANI, DAVAR. (2015). EVALUATION OF CD4+CD25+FOXP3+REGULATORY T-CELLS INCREASE IN TUMOR ENVIRONMENT OF INVASIVE INTRADUCTAL BREASTCARCINOMA AND CONTROL GROUP. PAJOUHESH DAR PEZESHKI, 39(2), 55-59. SID. https://sid.ir/paper/42104/en

Vancouver: Copy

OFOGHI MAHYA, MESDAGHI MEHRNAZ, KHALILNEZHAD AHAD, TAHERIPANAH ROBABEH, AMANI DAVAR. EVALUATION OF CD4+CD25+FOXP3+REGULATORY T-CELLS INCREASE IN TUMOR ENVIRONMENT OF INVASIVE INTRADUCTAL BREASTCARCINOMA AND CONTROL GROUP. PAJOUHESH DAR PEZESHKI[Internet]. 2015;39(2):55-59. Available from: https://sid.ir/paper/42104/en

IEEE: Copy

MAHYA OFOGHI, MEHRNAZ MESDAGHI, AHAD KHALILNEZHAD, ROBABEH TAHERIPANAH, and DAVAR AMANI, “EVALUATION OF CD4+CD25+FOXP3+REGULATORY T-CELLS INCREASE IN TUMOR ENVIRONMENT OF INVASIVE INTRADUCTAL BREASTCARCINOMA AND CONTROL GROUP,” PAJOUHESH DAR PEZESHKI, vol. 39, no. 2, pp. 55–59, 2015, [Online]. Available: https://sid.ir/paper/42104/en

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