EXPRESSION OF NATURAL CYTOTOXICITY RECEPTORS FROM PERIPHERAL BLOOD AND ADIPOSE TISSUE DERIVED NK CELLS FROM OBESE AND NON-OBESE PERSONS AND ITS EFFECT ON NEOPLASTIC CELLS

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HAMIDIEH AMIRALI; BEHFAR MARYAM; MOHSENI RASHIN; Shoae Hassani Alireza

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Journal: Research in Medicine Year:2018 | Volume:42 | Issue:1 Page(s): 7-14

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Title

EXPRESSION OF NATURAL CYTOTOXICITY RECEPTORS FROM PERIPHERAL BLOOD AND ADIPOSE TISSUE DERIVED NK CELLS FROM OBESE AND NON-OBESE PERSONS AND ITS EFFECT ON NEOPLASTIC CELLS

Author(s)

HAMIDIEH AMIRALI | BEHFAR MARYAM | MOHSENI RASHIN | Shoae Hassani Alireza | Issue Writer Certificate

Keywords

CANCERQ1

CELL THERAPYQ1

NATURAL KILLER CELLSQ1

STROMAL VASCULAR FRACTIONQ2

Abstract

Background: There are many types of leukocytes residing in subcutaneous adipose tissue among which NATURAL KILLER CELLS (NKs) comprise a major part. The aim of the present study was to study the expression of natural cytotoxicity receptors from peripheral blood and adipose tissue derived NK cells from obese and non-obese persons on its effect on neoplas tic cells. Materials and methods: In the current experimental survey, flow cytometry phenotyping was used to study the differences between the natural cytotoxicity receptor expression on ADNKs and PBNKs of both obese (BMI>30) and lean persons (BMI<25). The activation experiments on isolated and expanded NKs were performed using IL-2, IL-15, and IL-21 cytokines. Also, their cytotoxicity and cytokine production patterns were evaluated.Results: The activation experiments on NK cells revealed that the main population of the CD56dim within the total ADNKs of obese persons had an under-expression of NKp30 and NKp44 despite the unchanged levels of NKG2D.Conclusion: The data suggest the suppressive condition of the adipose tissue niche on the NKs response against sensitive neoplastic cells. As the NKs are the first line of the body’s defense against tumor formation, this change may lead to the development of transformed cells into the tumors.

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APA: Copy

HAMIDIEH, AMIRALI, BEHFAR, MARYAM, MOHSENI, RASHIN, & Shoae Hassani, Alireza. (2018). EXPRESSION OF NATURAL CYTOTOXICITY RECEPTORS FROM PERIPHERAL BLOOD AND ADIPOSE TISSUE DERIVED NK CELLS FROM OBESE AND NON-OBESE PERSONS AND ITS EFFECT ON NEOPLASTIC CELLS. PAJOUHESH DAR PEZESHKI, 42(1 ), 7-14. SID. https://sid.ir/paper/42213/en

Vancouver: Copy

HAMIDIEH AMIRALI, BEHFAR MARYAM, MOHSENI RASHIN, Shoae Hassani Alireza. EXPRESSION OF NATURAL CYTOTOXICITY RECEPTORS FROM PERIPHERAL BLOOD AND ADIPOSE TISSUE DERIVED NK CELLS FROM OBESE AND NON-OBESE PERSONS AND ITS EFFECT ON NEOPLASTIC CELLS. PAJOUHESH DAR PEZESHKI[Internet]. 2018;42(1 ):7-14. Available from: https://sid.ir/paper/42213/en

IEEE: Copy

AMIRALI HAMIDIEH, MARYAM BEHFAR, RASHIN MOHSENI, and Alireza Shoae Hassani, “EXPRESSION OF NATURAL CYTOTOXICITY RECEPTORS FROM PERIPHERAL BLOOD AND ADIPOSE TISSUE DERIVED NK CELLS FROM OBESE AND NON-OBESE PERSONS AND ITS EFFECT ON NEOPLASTIC CELLS,” PAJOUHESH DAR PEZESHKI, vol. 42, no. 1 , pp. 7–14, 2018, [Online]. Available: https://sid.ir/paper/42213/en

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