PROPHYLACTIC USE OF MITOMYCIN-C TO INHIBIT REGRESSION AND HAZE FORMATION AFTER PHOTOREFRACTIVE KERATECTOMY

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HASHEMI H.; TAHERI S.M.R.; FOTOUHI A.

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Journal: BINA Year:2003 | Volume:9 | Issue:1 (33) Page(s): 46-51

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Title

PROPHYLACTIC USE OF MITOMYCIN-C TO INHIBIT REGRESSION AND HAZE FORMATION AFTER PHOTOREFRACTIVE KERATECTOMY

Author(s)

HASHEMI H. | TAHERI S.M.R. | FOTOUHI A. | Issue Writer Certificate

Keywords

MITOMYCIN-CQ3

PRKQ3

MYOPIAQ3

CORNEAL HAZEQ3

Abstract

Purpose: To study the effect of prophylactic application of MITOMYCIN-C on regression and CORNEAL HAZE after photorefractive keratectomy (PRK) for high MYOPIA. Methods: Fifty-four eyes of 28 high myopic patients were enrolled in this prospective study. All eyes underwent PRK followed by 0.02% MITOMYCIN-C application for two minutes, washed with 15 to 20 ml of normal saline afterwards. All eyes were examined thoroughly on the first 7 days and one month after surgery, 48 eyes (88.9%) were evaluated at 3 and 6 months postoperatively. Hanna grading (in the scale of 0 to 4+) was used for assessment of CORNEAL HAZE. Results: Mean spherical equivalent refraction (SE) was –7.08±1.11 diopters (D), preoperatively. Six months after surgery, 37 eyes (77.1%) achieved uncorrected visual acuity (UCVA) of 20/20 or better and all eyes had an UCVA of 20/40 or better. At 6 months postoperatively, 45 (93.7%) of eyes had SE within ± 1.00D of emmetropia. One month postoperatively, 2 eyes (3.7%) had grade 0.5+ of haze, while at 3 and 6 months after surgery no visited eye had haze at all. There was no decrease in bestcorrected visual acuity after 6 months. In spatial frequencies of 6 and 12 cycle per degree contrast sensitivity decreased immediately after PRK and increased 1.5 lines by the 6th postoperative month compared to preoperative data. Conclusions: MITOMYCIN-C can prevent CORNEAL HAZE in treating high MYOPIA with PRK. PRK+ MITOMYCIN-C can be considered as an alternative method for treatment of myopic patients in whom corneal thickness is inadequate for laser in situ keratomileusis (LASIK). However, the results should be confirmed in longer follow-ups.

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APA: Copy

HASHEMI, H., TAHERI, S.M.R., & FOTOUHI, A.. (2003). PROPHYLACTIC USE OF MITOMYCIN-C TO INHIBIT REGRESSION AND HAZE FORMATION AFTER PHOTOREFRACTIVE KERATECTOMY. BINA, 9(1 (33)), 46-51. SID. https://sid.ir/paper/42281/en

Vancouver: Copy

HASHEMI H., TAHERI S.M.R., FOTOUHI A.. PROPHYLACTIC USE OF MITOMYCIN-C TO INHIBIT REGRESSION AND HAZE FORMATION AFTER PHOTOREFRACTIVE KERATECTOMY. BINA[Internet]. 2003;9(1 (33)):46-51. Available from: https://sid.ir/paper/42281/en

IEEE: Copy

H. HASHEMI, S.M.R. TAHERI, and A. FOTOUHI, “PROPHYLACTIC USE OF MITOMYCIN-C TO INHIBIT REGRESSION AND HAZE FORMATION AFTER PHOTOREFRACTIVE KERATECTOMY,” BINA, vol. 9, no. 1 (33), pp. 46–51, 2003, [Online]. Available: https://sid.ir/paper/42281/en

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