EARLY RESULTS OF AUTOLOGOUS CULTIVATED LIMBAL STEM CELL TRANSPLANTATION IN TOTAL LIMBAL STEM CELL DEFICIENCY

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JAVADI M.A.; EYN ELAHI BAHRAM; BARADARAN RAFIEI ALI REZA; BAHARVAND HOSSEIN; EBRAHIMI MARZIEH; RAFATI N.; REZAEI KANAVI M.

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Journal: BINA Year:2006 | Volume:11 | Issue:3 (44) Page(s): 275-288

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Title

EARLY RESULTS OF AUTOLOGOUS CULTIVATED LIMBAL STEM CELL TRANSPLANTATION IN TOTAL LIMBAL STEM CELL DEFICIENCY

Author(s)

Keywords

LIMBAL STEM CELL DEFICIENCYQ3

AMNIOTIC MEMBRANEQ3

CULTIVATED STEM CELL TRANSPLANTATIONQ3

EX VIVO EXPANSIONQ3

Abstract

Purpose: To report the early results of transplantation of autologous limbal stem cell cultivated on AMNIOTIC MEMBRANE in total LIMBAL STEM CELL DEFICIENCY.Methods: Four eye of 4 patients with total unilateral stem cell deficiency secondary to severe chemical or thermal burn were included. Stem cell deficiency was confirmed with impression cytology in all cases. Under topical anesthesia, a small limbal sector (1×1mm) was removed from the sound eye and cultivated on AMNIOTIC MEMBRANE. Cell expansions were transplanted to the affected eye 2 weeks later. Patients were regularly followed up. At each follow-upvisit, a complete eye examination with special attention to recurrence or regression of vascularization, corneal opacification, and healing of epithelial defect was performed. Digital imaging was performed at each follow-up visit. Impression cytology was repeated in all cases after surgery.Results: The patients were followed for 5-13 months. Decrease in corneal opacification and vascularization was obvious in 3 cases, in which the surface of the cornea was covered with corneal epithelium. Sectoral conjunctivalization was evident in these 3 cases, but their corneas were ready for corneal transplantation. The procedure failed in one case with total corneal conjunctivalization. Visual acuity improved in all cases.Conclusion: Autologous CULTIVATED STEM CELL TRANSPLANTATION on AMNIOTIC MEMBRANE seems to be an effective way for stem cell transplantation. More definite judgment needs longer follow-up together with long-term results of corneal transplantation in these patients.

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References

CULTURE AND PROLIFERATION OF HUMAN LIMBAL STEM CELLS IN VITRO

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APA: Copy

JAVADI, M.A., EYN ELAHI, BAHRAM, BARADARAN RAFIEI, ALI REZA, BAHARVAND, HOSSEIN, EBRAHIMI, MARZIEH, RAFATI, N., & REZAEI KANAVI, M.. (2006). EARLY RESULTS OF AUTOLOGOUS CULTIVATED LIMBAL STEM CELL TRANSPLANTATION IN TOTAL LIMBAL STEM CELL DEFICIENCY. BINA, 11(3 (44)), 275-288. SID. https://sid.ir/paper/42377/en

Vancouver: Copy

JAVADI M.A., EYN ELAHI BAHRAM, BARADARAN RAFIEI ALI REZA, BAHARVAND HOSSEIN, EBRAHIMI MARZIEH, RAFATI N., REZAEI KANAVI M.. EARLY RESULTS OF AUTOLOGOUS CULTIVATED LIMBAL STEM CELL TRANSPLANTATION IN TOTAL LIMBAL STEM CELL DEFICIENCY. BINA[Internet]. 2006;11(3 (44)):275-288. Available from: https://sid.ir/paper/42377/en

IEEE: Copy

M.A. JAVADI, BAHRAM EYN ELAHI, ALI REZA BARADARAN RAFIEI, HOSSEIN BAHARVAND, MARZIEH EBRAHIMI, N. RAFATI, and M. REZAEI KANAVI, “EARLY RESULTS OF AUTOLOGOUS CULTIVATED LIMBAL STEM CELL TRANSPLANTATION IN TOTAL LIMBAL STEM CELL DEFICIENCY,” BINA, vol. 11, no. 3 (44), pp. 275–288, 2006, [Online]. Available: https://sid.ir/paper/42377/en

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