SHORT-TERM OUTCOMES OF TRABECULECTOMY WITH INTRATENON INJECTION OF MMC VERSUS CONVENTIONAL METHOD

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HATAMI M.M.; PAKRAVAN M.; YAZDANI S.; DOUZANDEH A.; YASERI M.

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Journal: BINA Year:2017 | Volume:23 | Issue:1 Page(s): 13-21

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Title

SHORT-TERM OUTCOMES OF TRABECULECTOMY WITH INTRATENON INJECTION OF MMC VERSUS CONVENTIONAL METHOD

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Keywords

BLEB MORPHOLOGYQ2

INTRATENON INJECTIONQ1

MITOMYCIN CQ1

TRABECULECTOMYQ3

Abstract

Purpose: To compare the short-term outcomes of INTRATENON INJECTION of MITOMYCIN C (MMC) with the conventional application of MMC soaked sponges in TRABECULECTOMY.Methods: In this randomized clinical trial, 80 open angle glaucoma cases were randomly divided into 2 groups; group 1 received an INTRATENON INJECTION of 0.1 mL of 0.01% MMC, while group 2 received 0.02% MMC soaked sponges. Intraocular pressure (IOP), endothelial cell count (ECC) changes and BLEB MORPHOLOGY, according to the Indiana bleb appearance grading scale (IBAGS), were evaluated at 1, 3, and 6 months after surgery and compared between 2 groups. Complete and qualified success was defined as IOP within 6-15 mmHg without and with medications at month 6, respectively.Results: The mean preoperative IOP was 21.8±5.1 in group 1, which reduced to 10.3±3.7 mmHg at the final visit (P<0.001). Corresponding values for group 2 were 21.8±5 and 10.8±3.5 mmHg, respectively (P<0.001).Complete success was 82.5% and 87.5% in groups 1 and 2, respectively (P=0.526). The blebs tended to be more diffuse, shallower, and less vascularized in group 1, at month 6 (P=0.45, 0.001, and <0.001, respectively). Endothelial cell counts did not change significantly at the final visit (P=0.813).Conclusion: INTRATENON INJECTION of MMC is a safe and effective method and produces more favorable BLEB MORPHOLOGY after TRABECULECTOMY.

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APA: Copy

HATAMI, M.M., PAKRAVAN, M., YAZDANI, S., DOUZANDEH, A., & YASERI, M.. (2017). SHORT-TERM OUTCOMES OF TRABECULECTOMY WITH INTRATENON INJECTION OF MMC VERSUS CONVENTIONAL METHOD. BINA, 23(1 ), 13-21. SID. https://sid.ir/paper/42402/en

Vancouver: Copy

HATAMI M.M., PAKRAVAN M., YAZDANI S., DOUZANDEH A., YASERI M.. SHORT-TERM OUTCOMES OF TRABECULECTOMY WITH INTRATENON INJECTION OF MMC VERSUS CONVENTIONAL METHOD. BINA[Internet]. 2017;23(1 ):13-21. Available from: https://sid.ir/paper/42402/en

IEEE: Copy

M.M. HATAMI, M. PAKRAVAN, S. YAZDANI, A. DOUZANDEH, and M. YASERI, “SHORT-TERM OUTCOMES OF TRABECULECTOMY WITH INTRATENON INJECTION OF MMC VERSUS CONVENTIONAL METHOD,” BINA, vol. 23, no. 1 , pp. 13–21, 2017, [Online]. Available: https://sid.ir/paper/42402/en

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