MICROBIAL INHIBITIONAL IN NON-INFLAMED HUMAN AQUEOUS AFTER ORAL ANTIBIOTIC INTAKE

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KATBAB ASAD ELAH; AFROUZIFAR M.; ATARZADEH A.; NEJABAT M.; TALEBNEZHAD MOHAMMAD REZA

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Journal: BINA Year:2007 | Volume:12 | Issue:3 (48) Page(s): 326-330

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Title

MICROBIAL INHIBITIONAL IN NON-INFLAMED HUMAN AQUEOUS AFTER ORAL ANTIBIOTIC INTAKE

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Abstract

Purpose: To investigate the penetration of cefixime, cephalexin and ciprofloxacin into the human eye based on microbial inhibition by human aqueous samples after oral administration.Method: Sixty patients aged 40 to 75 years who were scheduled for cataract surgery were divided into three equal groups. One group received 500 mg oral ciprofloxacin 24, 12 and 2 hours preoperatively; another group received 500 mg oral cephalexin 24, 18, 12, 6 and 2 hours before the operation and the third group received 400 mg oral cefixime 24, 12 and 2 hours prior to surgery. Immediately before opening the anterior chamber, 0.1 ml of aqueous was taped with an insulin syringe. A 4 ml sample of the patient’s blood was obtained simultaneously. Aqueous and serum specimens as well as a standard antibiotic disc were placed on the culture media of a known bacterium which was completely sensitive to the respective antibiotic. After 48 hours microbial inhibition zone of each sample was compared to the standard antibiotic disc. Result: No microbial inhibition zone was seen by aqueous samples, however very large zones of inhibition were seen by discs of serum samples and antibiotics. Conclusion: It seems that oral cefixime, cephalexin and ciprofloxacin do not achieve effective concentrations in human aqueous for microbial inhibition.

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APA: Copy

KATBAB, ASAD ELAH, AFROUZIFAR, M., ATARZADEH, A., NEJABAT, M., & TALEBNEZHAD, MOHAMMAD REZA. (2007). MICROBIAL INHIBITIONAL IN NON-INFLAMED HUMAN AQUEOUS AFTER ORAL ANTIBIOTIC INTAKE. BINA, 12(3 (48)), 326-330. SID. https://sid.ir/paper/42854/en

Vancouver: Copy

KATBAB ASAD ELAH, AFROUZIFAR M., ATARZADEH A., NEJABAT M., TALEBNEZHAD MOHAMMAD REZA. MICROBIAL INHIBITIONAL IN NON-INFLAMED HUMAN AQUEOUS AFTER ORAL ANTIBIOTIC INTAKE. BINA[Internet]. 2007;12(3 (48)):326-330. Available from: https://sid.ir/paper/42854/en

IEEE: Copy

ASAD ELAH KATBAB, M. AFROUZIFAR, A. ATARZADEH, M. NEJABAT, and MOHAMMAD REZA TALEBNEZHAD, “MICROBIAL INHIBITIONAL IN NON-INFLAMED HUMAN AQUEOUS AFTER ORAL ANTIBIOTIC INTAKE,” BINA, vol. 12, no. 3 (48), pp. 326–330, 2007, [Online]. Available: https://sid.ir/paper/42854/en

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