ASSOCIATION OF THE DOPAMINE TRANSPORTER GENE (DAT1) CORE PROMOTOR POLYMORPHISM-67T ALLELE WITH SCHIZOPHRENIA

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OUHADI M.; FADAI F.; KHODAYARI N.; RAHIMI A.; NAJMABAD H.

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Journal: Archives of Rehabilitation (Journal of Rehabilitation) Year:2003 | Volume:4 | Issue:13 Page(s): 16-19

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Title

ASSOCIATION OF THE DOPAMINE TRANSPORTER GENE (DAT1) CORE PROMOTOR POLYMORPHISM-67T ALLELE WITH SCHIZOPHRENIA

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Keywords

DAT1Q4

PROMOTERQ4

SCHIZOPHRENIAQ2

ASSOCIATIONQ2

DOPAMINE POLYMORPHISMQ4

Abstract

Background: Dysfunction of the central dopaminergie neurotransmission has been suggested to play an important role in the etiology of SCHIZOPHRENIA. The dopamine transporter (DAT1) mediates the active reuptake of dopamine from the synapses and thereby plays a key role in the regulation of the dopaminergic neurotransmission. In this study, we sought to determine the possible ASSOCIATION of the DAT1 gene core PROMOTER polymorphism-67A/T with SCHIZOPHRENIA in a case/control study. Methods: The allele and genotype frequencies of the polymorphism were studied in 100 patients and 100 controls, which were matched on the basis of sex, age and ethnicity. Results: The genotype frequencies in the patients group were as follows: AA 29%, AT 59%, TT 12% vs. the genotype frequencies in the control group: AA 57%, AT 38%, TT 5%, [χ2=16.54, df-2, OR=2.25 (95% CI 1.46-3, 45, P≤0.0003)].Conclusion: For the first time, these findings provide tentalive evidence for the contribution of the DAT1 gene core PROMOTER polymorphism to the etioputhology of SCHIZOPHRENIA at least in the Iranian male population that we studied. Replication studies of independent samples and family-based ASSOCIATION studies are necessary to further evaluate the significance of our findings

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APA: Copy

OUHADI, M., FADAI, F., KHODAYARI, N., RAHIMI, A., & NAJMABAD, H.. (2003). ASSOCIATION OF THE DOPAMINE TRANSPORTER GENE (DAT1) CORE PROMOTOR POLYMORPHISM-67T ALLELE WITH SCHIZOPHRENIA. ARCHIVES OF REHABILITATION (JOURNAL OF REHABILITATION), 4(13), 16-19. SID. https://sid.ir/paper/43338/en

Vancouver: Copy

OUHADI M., FADAI F., KHODAYARI N., RAHIMI A., NAJMABAD H.. ASSOCIATION OF THE DOPAMINE TRANSPORTER GENE (DAT1) CORE PROMOTOR POLYMORPHISM-67T ALLELE WITH SCHIZOPHRENIA. ARCHIVES OF REHABILITATION (JOURNAL OF REHABILITATION)[Internet]. 2003;4(13):16-19. Available from: https://sid.ir/paper/43338/en

IEEE: Copy

M. OUHADI, F. FADAI, N. KHODAYARI, A. RAHIMI, and H. NAJMABAD, “ASSOCIATION OF THE DOPAMINE TRANSPORTER GENE (DAT1) CORE PROMOTOR POLYMORPHISM-67T ALLELE WITH SCHIZOPHRENIA,” ARCHIVES OF REHABILITATION (JOURNAL OF REHABILITATION), vol. 4, no. 13, pp. 16–19, 2003, [Online]. Available: https://sid.ir/paper/43338/en

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