EFFECT HONEY BEE VENOM AND L-ASCORBIC ACID (VITAMIN C) ON PROLIFERATION HL-60 PROMYELOCYTIC LEUKEMIA CELL LINE

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MOHSENI KOCHESFEHANI HOMA; NABIUNI MOHAMMAD; MIRSEPASI SARA; SAFAEINEJAD ZAHRA

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Paper Information

Journal: JOURNAL OF SCIENCE (KHARAZMI UNIVERSITY) Year:2010 | Volume:10 | Issue:3 Page(s): 945-958

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Title

EFFECT HONEY BEE VENOM AND L-ASCORBIC ACID (VITAMIN C) ON PROLIFERATION HL-60 PROMYELOCYTIC LEUKEMIA CELL LINE

Author(s)

MOHSENI KOCHESFEHANI HOMA | NABIUNI MOHAMMAD | MIRSEPASI SARA | SAFAEINEJAD ZAHRA | Issue Writer Certificate

Keywords

LQ3

ASCORBIC ACIDQ2

HONEY BEE VENOMQ3

HLQ3

60 ACUTE PROMYELOCYTIC LEUKEMIA CELL LINEQ3

ANTIQ3

PROLIFERATIONQ3

Abstract

Acute Promyelocytic Leukemia (APL) is a kind of acute Leukemia. L-Ascorbic Acid (L-AA) also known as Vitamin C has ANTI-oxidant properties. L-AA under certain conditions acts as a pro-oxidant and it has cytotoxic effect in high dose on different cell lines that this effect depends on its oxidation-reduction properties. Different experiments showed that ANTI-proliferation and ANTI- inflammation materials could influence the effect of such components and so decrease their resulting side effects. Regarding to ANTI-proliferative and ANTI-cancer HONEY BEE VENOM (BV), in this research, we examined the effect of BV on L-AA effect of function. The toxic and non-toxic concentrations of L-AA and BV on HL-60 cells were determined and then the effect of these two components individually and also in combination with each other on growth of HL-60 cells were assessed using Trypan blue stained cell counting and MTT assay. All experiments were done three times and data were analyzed using one-way ANOVA test and Instate 3 software. Our finding showed that both BV and L-AA caused cell death at high concentrations in a dose and time dependent manner in HL- these results, it may be suggested that non- toxic concentration of BV can increase ANTI-60 cells and they could inhibit PROLIFERATION of these cells at lower concentrations. L-AA in 0.1 mM concentration inhibited PROLIFERATION of HL-60 cells during 72 h and this inhibitory effect of L-AA significantly increased in combination with BV. On the basis of PROLIFERATION potency of L-AA on HL-60 cancer cell line.

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APA: Copy

MOHSENI KOCHESFEHANI, HOMA, NABIUNI, MOHAMMAD, MIRSEPASI, SARA, & SAFAEINEJAD, ZAHRA. (2010). EFFECT HONEY BEE VENOM AND L-ASCORBIC ACID (VITAMIN C) ON PROLIFERATION HL-60 PROMYELOCYTIC LEUKEMIA CELL LINE. JOURNAL OF SCIENCE (KHARAZMI UNIVERSITY), 10(3), 945-958. SID. https://sid.ir/paper/44073/en

Vancouver: Copy

MOHSENI KOCHESFEHANI HOMA, NABIUNI MOHAMMAD, MIRSEPASI SARA, SAFAEINEJAD ZAHRA. EFFECT HONEY BEE VENOM AND L-ASCORBIC ACID (VITAMIN C) ON PROLIFERATION HL-60 PROMYELOCYTIC LEUKEMIA CELL LINE. JOURNAL OF SCIENCE (KHARAZMI UNIVERSITY)[Internet]. 2010;10(3):945-958. Available from: https://sid.ir/paper/44073/en

IEEE: Copy

HOMA MOHSENI KOCHESFEHANI, MOHAMMAD NABIUNI, SARA MIRSEPASI, and ZAHRA SAFAEINEJAD, “EFFECT HONEY BEE VENOM AND L-ASCORBIC ACID (VITAMIN C) ON PROLIFERATION HL-60 PROMYELOCYTIC LEUKEMIA CELL LINE,” JOURNAL OF SCIENCE (KHARAZMI UNIVERSITY), vol. 10, no. 3, pp. 945–958, 2010, [Online]. Available: https://sid.ir/paper/44073/en

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