NANOBODY AND ITS THERAPEUTIC APPLICATIONS

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DARVISH MARYAM

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:28 | Issue:159 Page(s): 143-161

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Information Journal Paper

Title

NANOBODY AND ITS THERAPEUTIC APPLICATIONS

Author(s)

DARVISH MARYAM | Issue Writer Certificate

Keywords

NANOBODYQ2

VHHQ1

PHAGE DISPLAYQ2

MONOCLONAL ANTIBODIESQ3

Abstract

Background and purpose: MONOCLONAL ANTIBODIES market has grown since approval of Muromonab-CD3 (trade name Orthoclone OKT3) in 1986 as immuno-suppressor. Nevertheless, the undesirableeffects of these large specific biomolecules calls for further attempts for more effective alternatives. Variable domain of heavy chain (VHH) are the smallest antibody fragments called NANOBODY (Nb), derived from camelid heavy chain-only antibodies (HcAb) by DNA recombinant gene technology. In thisstudy, some of the unique structural and functional features of Nbs are summarized. The main context ofthis review speculate about several experimental therapeutic applications of Nbs against a wide range ofdiseases ranging from infectious, animal toxin, autoimmune, and cancer disease in three differentfunctional platforms. Data about structural and functional features of Nbs and their therapeutic effectswere retrieved from articles indexed in PubMed, Science direct, and Google Scholar. Development andemployment of Nbs in different researches show that their unique physicochemical properties make thema useful tool for biomedical applications and drug discovery. This is because of some exceptional featherssuch as small size, extraordinary stability, high affinity even for occluded epitopes, and cost-effectiveproduction. This review provides an overview of efficacy and success of Nbs as more promisingtherapeutic agents over conventional antibodies against multiple diseases.

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APA: Copy

DARVISH, MARYAM. (2018). NANOBODY AND ITS THERAPEUTIC APPLICATIONS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(159 ), 143-161. SID. https://sid.ir/paper/44152/en

Vancouver: Copy

DARVISH MARYAM. NANOBODY AND ITS THERAPEUTIC APPLICATIONS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;28(159 ):143-161. Available from: https://sid.ir/paper/44152/en

IEEE: Copy

MARYAM DARVISH, “NANOBODY AND ITS THERAPEUTIC APPLICATIONS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 159 , pp. 143–161, 2018, [Online]. Available: https://sid.ir/paper/44152/en

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