ANTIOXIDANT EFFECT OF LYCOPENE ON ORAL MUCOSITIS IN GAMMA RADIATION PROTECTION IN RATS (A PRELIMINARY STUDY)

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MOTALLEBNEJAD MINA; MOLANIA TAHEREH; MOGHADAMNIA ALI AKBAR; POURAMIR MAHDI; MOSLEMI DARUSH; KAZEMI SOHRAB; ZAHEDPASHA SHAGHAYEGH

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Journal: Journal of Mazandaran University of Medical Sciences Year:2018 | Volume:28 | Issue:159 Page(s): 137-142

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Title

ANTIOXIDANT EFFECT OF LYCOPENE ON ORAL MUCOSITIS IN GAMMA RADIATION PROTECTION IN RATS (A PRELIMINARY STUDY)

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Keywords

LYCOPENEQ2

MUCOSITISQ2

ANTIOXIDANTQ2

SERUMQ2

Abstract

Background and purpose: The ANTIOXIDANT property of LYCOPENE is well proven. The aim of thisstudy was to evaluate the effect of LYCOPENE on Oral MUCOSITIS (OM) in rat induced by gamma radiation. Materials and methods: This experimental study was conducted in 28 male Wistar rats. Theywere divided into four groups (n=7 per group). 15 Gy of gamma radiation was used for 7 min and 39 sec. The rats were intraperitoneally (IP) injected within 6 days (daily) and their lips and tongues wereexamined to assess the incidence and severity of MUCOSITIS. Blood samples were also taken from the miceon days zero and six and the SERUM total ANTIOXIDANT was evaluated by biochemical assays. Data analysiswas done in SPSS V18. One-way ANOVA was done to analyze the datasets for MUCOSITIS and SERUMantioxidant capacity. Mann– Whitney test was applied for pairwise comparison of therapeutic groups interms of the severity of MUCOSITIS. Results: LYCOPENE caused no delay in the onset of MUCOSITIS but the severity of MUCOSITIS waslower in LYCOPENE groups compared to that in the placebo group. According to FRAP test, totalantioxidant capacity changes of SERUM were significant between treatment groups on day six between L50and PR, L50 and LR25, PR and LR50, and LR25 and LR50 groups. Conclusion: LYCOPENE did not delay the onset of MUCOSITIS in treatment groups, but the severityof MUCOSITIS was lower in LYCOPENE groups compared with that in placebo group.

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APA: Copy

MOTALLEBNEJAD, MINA, MOLANIA, TAHEREH, MOGHADAMNIA, ALI AKBAR, POURAMIR, MAHDI, MOSLEMI, DARUSH, KAZEMI, SOHRAB, & ZAHEDPASHA, SHAGHAYEGH. (2018). ANTIOXIDANT EFFECT OF LYCOPENE ON ORAL MUCOSITIS IN GAMMA RADIATION PROTECTION IN RATS (A PRELIMINARY STUDY). JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(159 ), 137-142. SID. https://sid.ir/paper/44154/en

Vancouver: Copy

MOTALLEBNEJAD MINA, MOLANIA TAHEREH, MOGHADAMNIA ALI AKBAR, POURAMIR MAHDI, MOSLEMI DARUSH, KAZEMI SOHRAB, ZAHEDPASHA SHAGHAYEGH. ANTIOXIDANT EFFECT OF LYCOPENE ON ORAL MUCOSITIS IN GAMMA RADIATION PROTECTION IN RATS (A PRELIMINARY STUDY). JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;28(159 ):137-142. Available from: https://sid.ir/paper/44154/en

IEEE: Copy

MINA MOTALLEBNEJAD, TAHEREH MOLANIA, ALI AKBAR MOGHADAMNIA, MAHDI POURAMIR, DARUSH MOSLEMI, SOHRAB KAZEMI, and SHAGHAYEGH ZAHEDPASHA, “ANTIOXIDANT EFFECT OF LYCOPENE ON ORAL MUCOSITIS IN GAMMA RADIATION PROTECTION IN RATS (A PRELIMINARY STUDY),” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 159 , pp. 137–142, 2018, [Online]. Available: https://sid.ir/paper/44154/en

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