EFFECT OF SHILAJIT ON THE LEVELS OF PRO-INFLAMMATORY AND ANTIINFLAMMATION CYTOKINES IN HEPATIC INJURY IN MALE RATS

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GHAZI FIROZSALARI FARHOOD; SHAHROKHI NADER; KHAKSARI HADAD MOHAMMAD; ASADIKARAM GHOLAMREZA; Atashbar Jaber

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Journal: Journal of Mazandaran University of Medical Sciences Year:2018 | Volume:28 | Issue:159 Page(s): 1-13

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Title

EFFECT OF SHILAJIT ON THE LEVELS OF PRO-INFLAMMATORY AND ANTIINFLAMMATION CYTOKINES IN HEPATIC INJURY IN MALE RATS

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Keywords

SHILAJITQ1

ACETAMINOPHENQ3

BILE DUCTQ3

CYTOKINEQ2

LIVERQ2

Abstract

Background and purpose: CYTOKINEs regulate a broad range of biological and pathologicalprocesses. They play an important role in LIVER damage. Inflammatory and antioxidant factors areimportant causes of LIVER damage. SHILAJIT is known as an anti-inflammatory and antioxidant agent. Therefore, the main aim of this study was to determine the effect of SHILAJIT on levels of proinflammatoryand anti-inflammatory CYTOKINEs in LIVER injury. Materials and methods: In this experimental study, 80 male Wistar rats were randomly dividedinto two main groups: A and B. Each group was organized into five subgroups: control, ACETAMINOPHEN(A) or BILE DUCT obstruction (BDL) (B), low dose, high dose, and vehicle. All subgroups except thecontrols in group A received 500 mg/ kg ACETAMINOPHEN via IP injection, while BDL was performed in allsubgroups in group B. Then in group A, two hours and in group B seven days after injury, the treatmentsubgroups with drug and vehicle received 150 mg/kg (low dose) and 250 mg/kg (high dose)SHILAJIT anddistilled water as vehicle, for one and six days, respectively. After completing treatment, LIVER sampleswere taken for laboratory analysis. Results: Low-dose SHILAJIT treatment reduced IL-10, IL-6, IL-1β , and TNF-α levels, which hadbeen increased by a single dose of 500 mg/kg ACETAMINOPHEN (p<0. 05). Conclusion: SHILAJIT is effective in reducing inflammation and LIVER damage caused by high-doseconsumption of ACETAMINOPHEN.

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APA: Copy

GHAZI FIROZSALARI, FARHOOD, SHAHROKHI, NADER, KHAKSARI HADAD, MOHAMMAD, ASADIKARAM, GHOLAMREZA, & Atashbar, Jaber. (2018). EFFECT OF SHILAJIT ON THE LEVELS OF PRO-INFLAMMATORY AND ANTIINFLAMMATION CYTOKINES IN HEPATIC INJURY IN MALE RATS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(159 ), 1-13. SID. https://sid.ir/paper/44162/en

Vancouver: Copy

GHAZI FIROZSALARI FARHOOD, SHAHROKHI NADER, KHAKSARI HADAD MOHAMMAD, ASADIKARAM GHOLAMREZA, Atashbar Jaber. EFFECT OF SHILAJIT ON THE LEVELS OF PRO-INFLAMMATORY AND ANTIINFLAMMATION CYTOKINES IN HEPATIC INJURY IN MALE RATS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;28(159 ):1-13. Available from: https://sid.ir/paper/44162/en

IEEE: Copy

FARHOOD GHAZI FIROZSALARI, NADER SHAHROKHI, MOHAMMAD KHAKSARI HADAD, GHOLAMREZA ASADIKARAM, and Jaber Atashbar, “EFFECT OF SHILAJIT ON THE LEVELS OF PRO-INFLAMMATORY AND ANTIINFLAMMATION CYTOKINES IN HEPATIC INJURY IN MALE RATS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 159 , pp. 1–13, 2018, [Online]. Available: https://sid.ir/paper/44162/en

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