PROTECTIVE EFFECT OF ZINGIBER OFFICINALE AGAINST DIAZINON-INDUCED HEART INJURY VIA SUPPRESSION OF OXIDATIVE STRESS

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YAGHUBI BEKLAR SAEED; HAMZEH MAEDEH; TALEBPOUR AMIRI FERESHTEH

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Title

PROTECTIVE EFFECT OF ZINGIBER OFFICINALE AGAINST DIAZINON-INDUCED HEART INJURY VIA SUPPRESSION OF OXIDATIVE STRESS

Author(s)

YAGHUBI BEKLAR SAEED | HAMZEH MAEDEH | TALEBPOUR AMIRI FERESHTEH | Issue Writer Certificate

Keywords

ORGANOPHOSPHATE INSECTICIDESQ1

DIAZINONQ2

GINGERQ2

CARDIOTOXICITYQ1

OXIDATIVE STRESSQ2

Abstract

Background and purpose: DIAZINON (DZN), as an organophosphate insecticide, is used inagriculture and have destructive effects on heart. Zingiber officinale (ginger), as a medicinal plant hasantioxidant properties. This study was designed to evaluate the effect of GINGER against DZN-inducedcardiotoxicity in rats. Materials and methods: In this experimental study, 32 adult female Wistar rats were randomlydivided into 4 groups, including control, and experimental groups that received GINGER (100 mg/kg/day, gavage), DZN (10 mg/kg/day, IP injection), and GINGER plus DZN. GINGER was given one hour beforediazinon. All drugs were treated for 30 consecutive days. One day after receiving the last drug, oxidativestress parameters (MDA and GSH), serum biochemical, and histopathological assays of heart have beendone. Data were analysed using One-Way ANOVA and Tukey test. Results: The results revealed that DZN significantly increased OXIDATIVE STRESS (increased MDAand decreased GSH content). Histopathological changes induced in heart tissue, were associated with asignificant increase in level of cardiac injury markers (CPK and LDH level) in serum. GINGERsignificantly reduced OXIDATIVE STRESS, decreased CPK, LDH, and improved histopathological damages. Conclusion: GINGER with antioxidant activity has an effective role against DZN-induced cardiacinjury by reducing OXIDATIVE STRESS.

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APA: Copy

YAGHUBI BEKLAR, SAEED, HAMZEH, MAEDEH, & TALEBPOUR AMIRI, FERESHTEH. (2018). PROTECTIVE EFFECT OF ZINGIBER OFFICINALE AGAINST DIAZINON-INDUCED HEART INJURY VIA SUPPRESSION OF OXIDATIVE STRESS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 27(158 ), 15-26. SID. https://sid.ir/paper/44193/en

Vancouver: Copy

YAGHUBI BEKLAR SAEED, HAMZEH MAEDEH, TALEBPOUR AMIRI FERESHTEH. PROTECTIVE EFFECT OF ZINGIBER OFFICINALE AGAINST DIAZINON-INDUCED HEART INJURY VIA SUPPRESSION OF OXIDATIVE STRESS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;27(158 ):15-26. Available from: https://sid.ir/paper/44193/en

IEEE: Copy

SAEED YAGHUBI BEKLAR, MAEDEH HAMZEH, and FERESHTEH TALEBPOUR AMIRI, “PROTECTIVE EFFECT OF ZINGIBER OFFICINALE AGAINST DIAZINON-INDUCED HEART INJURY VIA SUPPRESSION OF OXIDATIVE STRESS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 158 , pp. 15–26, 2018, [Online]. Available: https://sid.ir/paper/44193/en

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