ADVANCED MUSCULOSKELETAL INVOLVEMENT IN AN OLD PATIENT WITH SICKLE CELL DISEASE: A RARE CASE

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MOBINI MARYAM; NAMADCHIAN ZAHRA; SHEKARRIZ RAMIN; MAJIDI HADI

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Title

ADVANCED MUSCULOSKELETAL INVOLVEMENT IN AN OLD PATIENT WITH SICKLE CELL DISEASE: A RARE CASE

Author(s)

MOBINI MARYAM | NAMADCHIAN ZAHRA | SHEKARRIZ RAMIN | MAJIDI HADI | Issue Writer Certificate

Keywords

SICKLE CELL DISEASEQ3

BONEQ3

OSTEONECROSISQ1

Abstract

SICKLE CELL DISEASE is the most common type of hemoglobinopathies in the world that is caused by abnormal beta globin chain in hemoglobin. The disease is usually diagnosed in the first decade of life. BONE involvement is one of the most common clinical manifestations both in the acute setting (painful vaso-occlusive crises), and/or as a source of chronic disability (such as avascular necrosis). This paper introduces an old patient with advanced skeletal manifestation due to this disorder. A 66-year-old man who was opium abuser was visited by a rheumatologist for lower limbs pain, and fatigue from one year ago. The patient had severe anemia, and X-ray revealed diffuse osteolytic changes without sharp border in pelvis and femur and joint space narrowing. Involvement of thoracolumbar vertebras were seen as codfish vertebra appearance. In peripheral blood smear, sickle cell and target cells accompanied by hypochromia and platelets aggregation were detected. The hemoglobin electrophoresis was compatible with sickle-b+ thalassemia. In old patients with anemia and osteolytic lesions with unknown reason, evaluation of hemoglobinopathies, especially sickle cell anemia is suggested.

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APA: Copy

MOBINI, MARYAM, NAMADCHIAN, ZAHRA, SHEKARRIZ, RAMIN, & MAJIDI, HADI. (2016). ADVANCED MUSCULOSKELETAL INVOLVEMENT IN AN OLD PATIENT WITH SICKLE CELL DISEASE: A RARE CASE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 26(138), 203-208. SID. https://sid.ir/paper/44224/en

Vancouver: Copy

MOBINI MARYAM, NAMADCHIAN ZAHRA, SHEKARRIZ RAMIN, MAJIDI HADI. ADVANCED MUSCULOSKELETAL INVOLVEMENT IN AN OLD PATIENT WITH SICKLE CELL DISEASE: A RARE CASE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;26(138):203-208. Available from: https://sid.ir/paper/44224/en

IEEE: Copy

MARYAM MOBINI, ZAHRA NAMADCHIAN, RAMIN SHEKARRIZ, and HADI MAJIDI, “ADVANCED MUSCULOSKELETAL INVOLVEMENT IN AN OLD PATIENT WITH SICKLE CELL DISEASE: A RARE CASE,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 138, pp. 203–208, 2016, [Online]. Available: https://sid.ir/paper/44224/en

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