COMPARING THE EXPRESSION LEVELS OF MRNA FOR MMP-7 IN GASTRIC MUCOSA OF PATIENTS WITH H. PYLORI INFECTION AND UNINFECTED PATIENTS

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SADEGHIANI MARZIEH; SHAHI HESHMAT; BAGHERI NADER; REIISI SOMAYEH; RAHIMIAN GHORBANALI; RASHIDII REZA; SHAFIGHEARDESTANI MOHAMMADHADI; HASHEMZADEH CHALESHTORI MORTEZA; RAFIEIAN KOPAEI MAHMOUD; RAMEZANI GHASEM; FATOLLAHI FERESHTEH; SHAHVERDI ELAHEH; SHIRZAD HEDAYATOLLAH

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2016 | Volume:26 | Issue:138 Page(s): 108-117

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Title

COMPARING THE EXPRESSION LEVELS OF MRNA FOR MMP-7 IN GASTRIC MUCOSA OF PATIENTS WITH H. PYLORI INFECTION AND UNINFECTED PATIENTS

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Keywords

HELICOBACTER PYLORIQ3

MATRIX METALLOPROTEINASE-7Q1

GASTROINTESTINAL DISEASESQ2

REAL-TIME PCRQ2

Abstract

Background and purpose: The expression of growth factors, proteolytic enzymes, fibrogenic factors, and cytokines are altered in HELICOBACTER PYLORI (H. pylori) infected gastric mucosa. Matrix metalloproteinases (MMP) are a family of zinc-dependent homologous enzymes digesting most of the components of the extracellular matrix and basement membrane and are involved in remodeling and functioning of the biological processes. The purpose of this study was to compare gene expression of MATRIX METALLOPROTEINASE-7 (MMP-7) in patients with H. pylori-infected and uninfected individuals with GASTROINTESTINAL DISEASES.Materials and methods: This study was conducted in 50 H. pylori-negative patients and 50 H. pylori-positive patients being admitted to Shahrekord Hajar Hospital due to GASTROINTESTINAL DISEASES in 2014. The participants’ demographic information was collected and sampling was done. First DNA was extracted, and then PCR was performed to check for the presence of 16sRNA and UreC. The RNA from each sample was also extracted and cDNA was prepared. Afterwards, the expression of MMP-7 was measured by real time-PCR using specific primers and probes.Results: MMP-7 mRNA expression was significantly higher in biopsies of H. pylori-infected patients compared to that in H. pylori-uninfected patients (P<0.0001).Conclusion: Increased expression of MMP-7 can be effective in inflammatory response and development of the disease. It could be used as a key marker for early diagnosis of GASTROINTESTINAL DISEASES and gastric cancer.

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APA: Copy

SADEGHIANI, MARZIEH, SHAHI, HESHMAT, BAGHERI, NADER, REIISI, SOMAYEH, RAHIMIAN, GHORBANALI, RASHIDII, REZA, SHAFIGHEARDESTANI, MOHAMMADHADI, HASHEMZADEH CHALESHTORI, MORTEZA, RAFIEIAN KOPAEI, MAHMOUD, FATOLLAHI, FERESHTEH, SHAHVERDI, ELAHEH, SHIRZAD, HEDAYATOLLAH, & RAMEZANI, GHASEM. (2016). COMPARING THE EXPRESSION LEVELS OF MRNA FOR MMP-7 IN GASTRIC MUCOSA OF PATIENTS WITH H. PYLORI INFECTION AND UNINFECTED PATIENTS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 26(138), 108-117. SID. https://sid.ir/paper/44228/en

Vancouver: Copy

SADEGHIANI MARZIEH, SHAHI HESHMAT, BAGHERI NADER, REIISI SOMAYEH, RAHIMIAN GHORBANALI, RASHIDII REZA, SHAFIGHEARDESTANI MOHAMMADHADI, HASHEMZADEH CHALESHTORI MORTEZA, RAFIEIAN KOPAEI MAHMOUD, FATOLLAHI FERESHTEH, SHAHVERDI ELAHEH, SHIRZAD HEDAYATOLLAH, RAMEZANI GHASEM. COMPARING THE EXPRESSION LEVELS OF MRNA FOR MMP-7 IN GASTRIC MUCOSA OF PATIENTS WITH H. PYLORI INFECTION AND UNINFECTED PATIENTS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;26(138):108-117. Available from: https://sid.ir/paper/44228/en

IEEE: Copy

MARZIEH SADEGHIANI, HESHMAT SHAHI, NADER BAGHERI, SOMAYEH REIISI, GHORBANALI RAHIMIAN, REZA RASHIDII, MOHAMMADHADI SHAFIGHEARDESTANI, MORTEZA HASHEMZADEH CHALESHTORI, MAHMOUD RAFIEIAN KOPAEI, FERESHTEH FATOLLAHI, ELAHEH SHAHVERDI, HEDAYATOLLAH SHIRZAD, and GHASEM RAMEZANI, “COMPARING THE EXPRESSION LEVELS OF MRNA FOR MMP-7 IN GASTRIC MUCOSA OF PATIENTS WITH H. PYLORI INFECTION AND UNINFECTED PATIENTS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 138, pp. 108–117, 2016, [Online]. Available: https://sid.ir/paper/44228/en

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