EVALUATION OF COMBINATION THERAPY WITH INTERFERON AND RIBAVIRIN IN PATIENTS WITH CHRONIC HEPATITIS C: A GENOTYPE BASED STUDY

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BAFANDEH Y.; SABERI FIROUZI M.; BAGHERI LANKARANI KAMRAN

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2007 | Volume:17 | Issue:57 Page(s): 9-16

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Title

EVALUATION OF COMBINATION THERAPY WITH INTERFERON AND RIBAVIRIN IN PATIENTS WITH CHRONIC HEPATITIS C: A GENOTYPE BASED STUDY

Author(s)

BAFANDEH Y. | SABERI FIROUZI M. | BAGHERI LANKARANI KAMRAN | Issue Writer Certificate

Keywords

CHRONIC HEPATITIS CQ3

INTERFERON AND RIBAVIRINQ3

THERAPYQ3

GENOTYPINGQ2

IRANQ2

Abstract

Background and purpose: About 200,000 of IRANian population are infected with Hepatitis C Virus. On the basis of IRANian consensus on management of CHRONIC HEPATITIS C (CHC) infection in 2004, combination THERAPY with conventional α-Interferon (IFN) plus Ribavirin is the first therapeutic choice in CHC patients. Data are limited on treatment response rate in most areas of the country. To assess the treatment results, we performed this study in a referral center in province of Fars, in IRAN, to compare with the response rates to THERAPY in Western patients.Materials and Methods: A total of 118 patients with CHC (males 88%) with mean age of 37.47 (SD 11.4) years, mean Histologic Activity Index of 8.21 (SD 4.5), and mean pretreatment Alt level of 81.26 (SD 72.86) were enrolled in the study. IFN 3 million unit/TIW plus Ribavirin 1-1.2 gr/d were administrated for 6-12 months (depending on genotype), and the patients were followed up for 6 months period to assess sustained virologic response (SVR).Results: The most common route of acquisition of the virus was intravenous drug using seen in 39.8% of patients. 40.7% were infected by genotype 3a, 22% 1a and 9.3% by 1b.Seventy-three patients completed the course of THERAPY. End of treatment response (ETR) was achieved in 54 (74%) patients. SVR rate was 48% with a relapse of 13.7%. Hepatic decomposition was seen in 2 (2.7%) patients in follow-up period. With respect to the duration of THERAPY, genotype of viruses was not significantly different in both responders and non-responders (0.05).Conclusion: Despite the different GENOTYPING pattern, ETR and SVR rates were comparable in IRANian CHC patients treated by combination THERAPY of conventional IFN plus ribavirin in comparison with Western patients. SVR was greater in cases with pretreatment lower HAI.

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APA: Copy

BAFANDEH, Y., SABERI FIROUZI, M., & BAGHERI LANKARANI, KAMRAN. (2007). EVALUATION OF COMBINATION THERAPY WITH INTERFERON AND RIBAVIRIN IN PATIENTS WITH CHRONIC HEPATITIS C: A GENOTYPE BASED STUDY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 17(57), 9-16. SID. https://sid.ir/paper/44283/en

Vancouver: Copy

BAFANDEH Y., SABERI FIROUZI M., BAGHERI LANKARANI KAMRAN. EVALUATION OF COMBINATION THERAPY WITH INTERFERON AND RIBAVIRIN IN PATIENTS WITH CHRONIC HEPATITIS C: A GENOTYPE BASED STUDY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2007;17(57):9-16. Available from: https://sid.ir/paper/44283/en

IEEE: Copy

Y. BAFANDEH, M. SABERI FIROUZI, and KAMRAN BAGHERI LANKARANI, “EVALUATION OF COMBINATION THERAPY WITH INTERFERON AND RIBAVIRIN IN PATIENTS WITH CHRONIC HEPATITIS C: A GENOTYPE BASED STUDY,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 17, no. 57, pp. 9–16, 2007, [Online]. Available: https://sid.ir/paper/44283/en

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