LONG-TERM EFFECTS OF PEG-INTERFERON ALFA-2A AND RIBAVIRIN IN HEMOPHILIC PATIENTS WITH CHRONIC HEPATITIS C

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KHALEGHI SIAMAK; TALEBI TAHER MAHSHID; AHI SALMA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Medical Sciences Journal of Islamic Azad University,Tehran Medical Branch Year:2012 | Volume:22 | Issue:2 Page(s): 157-162

Download Full-Text

Persian Verion

View:

758

Download:

Cites:

Information Journal Paper

Title

LONG-TERM EFFECTS OF PEG-INTERFERON ALFA-2A AND RIBAVIRIN IN HEMOPHILIC PATIENTS WITH CHRONIC HEPATITIS C

Author(s)

KHALEGHI SIAMAK | TALEBI TAHER MAHSHID | AHI SALMA | Issue Writer Certificate

Keywords

HEMOPHILIAQ3

HEPATITIS CQ2

TREATMENTQ2

PEG-INTERFERONE ALFA2-AQ3

RIBAVIRINQ3

Abstract

Background: chronic HEPATITIS C infection is a major health problem in HEMOPHILIA patients. There is no enough evidence about the long term outcome and efficacy of TREATMENT in these patients. The aim of this study was to evaluate the clinical, biochemical and virologic outcome of chronic HEPATITIS C treated with peg interferon alfa2-a and RIBAVIRIN in HEMOPHILIA patients during a five- year follow up.Materials and Methods: In a retrospective cohort study, 35 HEMOPHILIA patients with chronic HCV infection who were treated by peg interferon and RIBAVIRIN were studied. The efficacy of therapy was expressed as sustained virologic response (SVR: undetectable HCVRNA after six month of standard therapy). Association of efficacy of therapy and genotyping were analyzed by chi-square using SPSS ver.15 software. P<0.05 was considered statistically significant.Results: twenty seven patients (93.1%) achieved SVR, six patients did not respond. Follow up after 3 and 5years of TREATMENT showed the same results.No evidence of virologic, biochemical and clinical relapse were detected. None of the patients were demonstrated hepatitis decompensating or hepatocellular carcinoma.Conclusion: It seems that sustained virologic response and the absence of clinical, virologic relapse after long term follow up (5 years) means the rescue from the fetal hepatitis infection.

Cites

No record.

References

Cite

APA: Copy

KHALEGHI, SIAMAK, TALEBI TAHER, MAHSHID, & AHI, SALMA. (2012). LONG-TERM EFFECTS OF PEG-INTERFERON ALFA-2A AND RIBAVIRIN IN HEMOPHILIC PATIENTS WITH CHRONIC HEPATITIS C. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 22(2), 157-162. SID. https://sid.ir/paper/98723/en

Vancouver: Copy

KHALEGHI SIAMAK, TALEBI TAHER MAHSHID, AHI SALMA. LONG-TERM EFFECTS OF PEG-INTERFERON ALFA-2A AND RIBAVIRIN IN HEMOPHILIC PATIENTS WITH CHRONIC HEPATITIS C. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2012;22(2):157-162. Available from: https://sid.ir/paper/98723/en

IEEE: Copy

SIAMAK KHALEGHI, MAHSHID TALEBI TAHER, and SALMA AHI, “LONG-TERM EFFECTS OF PEG-INTERFERON ALFA-2A AND RIBAVIRIN IN HEMOPHILIC PATIENTS WITH CHRONIC HEPATITIS C,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 22, no. 2, pp. 157–162, 2012, [Online]. Available: https://sid.ir/paper/98723/en

Related Journal Papers