EVALUATION OF SERUM LEVEL OF IL-12 IN PATIENTS WITH OCCULT HBV INFECTION

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KAZEMI ARABABADI M.; POURFATH ELAH A.A.; HASANSHAHI GH.H.; POULADVAND V.; YAGHINI N.; SHAMSIZADEH ALI

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2010 | Volume:19 | Issue:73 Page(s): 80-83

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Title

EVALUATION OF SERUM LEVEL OF IL-12 IN PATIENTS WITH OCCULT HBV INFECTION

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Keywords

OCCULT HEPATITIS B INFECTIONQ3

IL-12Q3

HBSAGQ3

HBV-DNAQ3

Abstract

Background and purpose: OCCULT HEPATITIS B INFECTION (OBI) is a form of hepatitis in which despite the absence of detectable HBSAG, HBV-DNA is present in peripheral blood of patients. Investigators believed that the genetics and immunological parameters may be different in resistant individuals and patients. Cytokines, such as IL-12, could be leading to alteration in viral immune response. The main aim of this study was to investigate the serum level of IL12 in OBI patients.Materials and methods: In this study, the plasma samples of 3700 HBSAG negative blood donors were tested for anti-HBs by ELISA. The HBSAG negative and anti-HBc positive samples were selected and screened for HBV-DNA by PCR. HBV-DNA positive samples were assigned as OBI cases and ELISA technique were performed to examine the serum level of IL-12 in OBI and 100 healthy controls.Results: Our results showed that there was no significant difference in serum level of IL-12 between OBI patients and controls.Conclusion: In order to be clear of viruses, L-12 is increased in viral infection. Based on the results of this study, it is concluded that OBI patients can not produce enough IL-12 to clear HBV.

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APA: Copy

KAZEMI ARABABADI, M., POURFATH ELAH, A.A., HASANSHAHI, GH.H., POULADVAND, V., YAGHINI, N., & SHAMSIZADEH, ALI. (2010). EVALUATION OF SERUM LEVEL OF IL-12 IN PATIENTS WITH OCCULT HBV INFECTION. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 19(73), 80-83. SID. https://sid.ir/paper/44297/en

Vancouver: Copy

KAZEMI ARABABADI M., POURFATH ELAH A.A., HASANSHAHI GH.H., POULADVAND V., YAGHINI N., SHAMSIZADEH ALI. EVALUATION OF SERUM LEVEL OF IL-12 IN PATIENTS WITH OCCULT HBV INFECTION. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2010;19(73):80-83. Available from: https://sid.ir/paper/44297/en

IEEE: Copy

M. KAZEMI ARABABADI, A.A. POURFATH ELAH, GH.H. HASANSHAHI, V. POULADVAND, N. YAGHINI, and ALI SHAMSIZADEH, “EVALUATION OF SERUM LEVEL OF IL-12 IN PATIENTS WITH OCCULT HBV INFECTION,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 19, no. 73, pp. 80–83, 2010, [Online]. Available: https://sid.ir/paper/44297/en

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