DETECTION OF THE CCR5-δ 32 MUTATION IN PATIENTS INFECTED WITH OCCULT HEPATITIS B

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KAZEMI ARABABADI M.; POURFATH ELAH A.A.; JAFARZADEH A.A.; HASANSHAHI GH.H.; AFROUZ M.R.; HADADIAN M.

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Journal: Zahedan Journal of Research in Medical Sciences Year:2009 | Volume:11 | Issue:2 Page(s): 41-48

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Title

DETECTION OF THE CCR5-δ 32 MUTATION IN PATIENTS INFECTED WITH OCCULT HEPATITIS B

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Keywords

OCCULT HEPATITIS B INFECTIONQ3

CCR5Q3

HBSAGQ3

HBV-DNAQ3

δ32 MUTATIONQ3

Abstract

Background: OCCULT HEPATITIS B INFECTION (OBI) is a form of viral hepatitis in which the HBVDNA is present in blood while the HBSAG is undetectable. As differences in genetics and immunological responses have important role on OBI we were persuaded to analyze the known CCR5-D32 mutation (a chemokine receptor) in patients with OBI.Materials and Methods: In this descriptive study, 3700 blood samples that were HBSAG negative were collected during March 2006 to February 2007, from Rafsanjan blood transfusion services. All samples were tested for anti-HBc antibody. The HBSAG negative and anti-HBc positive samples were analyzed for HBV-DNA by PCR technique. The HBV-DNA positive samples were regarded as OBI cases. Finally, the Gap-PCR was performed to examine the d32 mutation in OBI patients. Results: The analysis of results showed that 352 (9.51%) cases of HBSAG negative samples were positive for anti-HBc. Following examination of HBSAG negative and anti-HBc positive samples for HBV-DNA by PCR based methods; we found that 57(16.1%) cases had HBV-DNA. None of the OBI patients had d32 mutation in CCR5 chemokine receptor whereas 2(2%) of controls had heterozigotic form of this mutation.Conclusion: Based on the results of this study it seems that CCR5-D32 mutation does not affect the immune response against HBV to make OBI.

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APA: Copy

KAZEMI ARABABADI, M., POURFATH ELAH, A.A., JAFARZADEH, A.A., HASANSHAHI, GH.H., AFROUZ, M.R., & HADADIAN, M.. (2009). DETECTION OF THE CCR5-δ 32 MUTATION IN PATIENTS INFECTED WITH OCCULT HEPATITIS B. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 11(2), 41-48. SID. https://sid.ir/paper/84294/en

Vancouver: Copy

KAZEMI ARABABADI M., POURFATH ELAH A.A., JAFARZADEH A.A., HASANSHAHI GH.H., AFROUZ M.R., HADADIAN M.. DETECTION OF THE CCR5-δ 32 MUTATION IN PATIENTS INFECTED WITH OCCULT HEPATITIS B. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2009;11(2):41-48. Available from: https://sid.ir/paper/84294/en

IEEE: Copy

M. KAZEMI ARABABADI, A.A. POURFATH ELAH, A.A. JAFARZADEH, GH.H. HASANSHAHI, M.R. AFROUZ, and M. HADADIAN, “DETECTION OF THE CCR5-δ 32 MUTATION IN PATIENTS INFECTED WITH OCCULT HEPATITIS B,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 11, no. 2, pp. 41–48, 2009, [Online]. Available: https://sid.ir/paper/84294/en

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