THE STUDY REGARDING EFFECT OF PARAOXON ON OXIDATIVE STRESS INDEX IN KIDNEY TISSUE OF RATS

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ABBASNEJAD MARYAM; JAFARI MAHVASH; ASGARI ALI REZA; HAJI HOSSEINI REZA; HAJI GHOLAMALI M.; SALEHI MARYAM; SALIMIAN M.

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2010 | Volume:19 | Issue:73 Page(s): 16-26

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Title

THE STUDY REGARDING EFFECT OF PARAOXON ON OXIDATIVE STRESS INDEX IN KIDNEY TISSUE OF RATS

Author(s)

Keywords

PARAOXONQ2

OXIDATIVE STRESS INDEXQ3

RATQ2

KIDNEY TISSUEQ2

Abstract

Background and purpose: PARAOXON is the active form of parathion, which is an organophosphate pesticide (OP). The toxic effects of some OPs are not limited to inhibition of cholinesterase, they are capable to produce free radicals and induce disturbance in body antioxidant systems. The purpose of this study was to evaluate the effect of PARAOXON on OXIDATIVE STRESS INDEXin the kidney of RAT.Materials and methods:Wistar male RATs were randomly divided in four groups including: control (corn oil as PARAOXON solvent) and three PARAOXON groups receiving different doses (0.3, 0.7 and 1mg/kg) by intraperitoneal injection. 24 hours after injection, animal was given anesthesia and KIDNEY TISSUE removed. After KIDNEY TISSUE hemogenation, superoxidedismutase (SOD) and catalase (CAT), lactate dehydrogenase (LDH) and glutathione S- transferase (GST) activities, glutathione (GSH) and malondialdehyde (MDA) levels were determined by biochemical methods.Results: At doses higher than 0.3 mg/kg PARAOXON, kidney SOD and CAT activities were significantly increased, comparing with the control, while GSH level was significantly decreased. There were no significant changes observed in GST, LDH activities and MDA levels.Conclusion: The results suggest that PARAOXON induces the production of free radicals and oxidative stress. The enhanced activity of antioxidant enzymes in kidney of RATs probably was a function of the increased detoxification capacity. Depletion of tissue GSH is a prime factor, which can impair the cell’s defense against the toxic actions of free radicals.

Cites

THE EFFECT OF SAFFRON SUPPLEMENTATION OF ANTIOXIDANT ENZYMES ACTIVITIES DURING A SESSION ECCENTRIC EXERCISE IN ACTIVE MALES

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APA: Copy

ABBASNEJAD, MARYAM, JAFARI, MAHVASH, ASGARI, ALI REZA, HAJI HOSSEINI, REZA, HAJI GHOLAMALI, M., SALEHI, MARYAM, & SALIMIAN, M.. (2010). THE STUDY REGARDING EFFECT OF PARAOXON ON OXIDATIVE STRESS INDEX IN KIDNEY TISSUE OF RATS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 19(73), 16-26. SID. https://sid.ir/paper/44299/en

Vancouver: Copy

ABBASNEJAD MARYAM, JAFARI MAHVASH, ASGARI ALI REZA, HAJI HOSSEINI REZA, HAJI GHOLAMALI M., SALEHI MARYAM, SALIMIAN M.. THE STUDY REGARDING EFFECT OF PARAOXON ON OXIDATIVE STRESS INDEX IN KIDNEY TISSUE OF RATS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2010;19(73):16-26. Available from: https://sid.ir/paper/44299/en

IEEE: Copy

MARYAM ABBASNEJAD, MAHVASH JAFARI, ALI REZA ASGARI, REZA HAJI HOSSEINI, M. HAJI GHOLAMALI, MARYAM SALEHI, and M. SALIMIAN, “THE STUDY REGARDING EFFECT OF PARAOXON ON OXIDATIVE STRESS INDEX IN KIDNEY TISSUE OF RATS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 19, no. 73, pp. 16–26, 2010, [Online]. Available: https://sid.ir/paper/44299/en

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