IMMUNOGENICITY OF LOW DOSE INTRADERMAL HEPATITIS B VACCINE

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SAFAAR M.J.; KOUSARIAN M.; MOHAMMAD JAFARI H.

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2002 | Volume:11 | Issue:33 Page(s): 57-62

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Information Journal Paper

Title

IMMUNOGENICITY OF LOW DOSE INTRADERMAL HEPATITIS B VACCINE

Author(s)

SAFAAR M.J. | KOUSARIAN M. | MOHAMMAD JAFARI H. | Issue Writer Certificate

Keywords

HEPATITIS BQ3

INTRADERMAL VACCINATIONQ4

LOW DOSEQ4

INTRA MUSCULARQ4

Abstract

Background and purpose: HEPATITIS B viral infection (NBI) and its sequelae are a major worldwide health problem. The most effective way to contral and prevent HBI is univerral immunization with HEPATITIS B vaccine (HBI). But the most limitation of it is inadequate resource. The aim of this study is to evaluate the immunogenitity of LOW DOSE immtradermal (ID) HBV, according to routine intramuscular (IM) route.Materials and Methods: A clinical trial study on 113 fullterm neonates from HBSAg. Negative mothers in two case and control groups were conduted. Case group received 2 µg ID HBV, and contral group recived 10 µg IM HBV at 0.105 and 6 moths of age. 4 wks after last dose serum Anti HBSAg Antibody titer was quantitied by ELISA.Results: The results showed 19 out of 23 (82.6%) in case and 27 out of 28 (96.4%) in control group had complete response (10 IU/ml ≤). The difference by X2 was not significant. The mean geometelic titer (GMT) in case was 447±336 and in contral 658±378, the difference by X2 was significant. Conclusion: According to obtained data, LOW DOSE ID HBV can induce comparable immunologic response. But funther studies with larger sample size and detection of durability of protection isneeded.

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References

مقایسه تاثیر واکسن هپاتیت B به روشهای داخل عضلانی و داخل جلدی

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APA: Copy

SAFAAR, M.J., KOUSARIAN, M., & MOHAMMAD JAFARI, H.. (2002). IMMUNOGENICITY OF LOW DOSE INTRADERMAL HEPATITIS B VACCINE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 11(33), 57-62. SID. https://sid.ir/paper/44512/en

Vancouver: Copy

SAFAAR M.J., KOUSARIAN M., MOHAMMAD JAFARI H.. IMMUNOGENICITY OF LOW DOSE INTRADERMAL HEPATITIS B VACCINE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2002;11(33):57-62. Available from: https://sid.ir/paper/44512/en

IEEE: Copy

M.J. SAFAAR, M. KOUSARIAN, and H. MOHAMMAD JAFARI, “IMMUNOGENICITY OF LOW DOSE INTRADERMAL HEPATITIS B VACCINE,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 11, no. 33, pp. 57–62, 2002, [Online]. Available: https://sid.ir/paper/44512/en

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