LONG-TERM ANTIBODY RESPONSE AND IMMUNOLOGIC MEMORY IN CHILDREN IMMUNIZED WITH HEPATITIS B VACCINE AT BIRTH

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SAFAAR M.J.; REZAEI M.S.

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Journal: Koomesh Year:2004 | Volume:5 | Issue:1-2 Page(s): 63-71

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Title

LONG-TERM ANTIBODY RESPONSE AND IMMUNOLOGIC MEMORY IN CHILDREN IMMUNIZED WITH HEPATITIS B VACCINE AT BIRTH

Author(s)

SAFAAR M.J. | REZAEI M.S. | Issue Writer Certificate

Keywords

HEPATITIS B VACCINEQ3

BOOSTER DOSE VACCINATIONQ3

IMMUNOLOGIC MEMORYQ4

LONG-TERM IMMUNITYQ4

Abstract

Introduction: To evaluate the LONG-TERM IMMUNITY and IMMUNOLOGIC MEMORY provided by universal hepatitis B vaccination program at birth, and to evaluate the booster effects of different dosages of HEPATITIS B VACCINE on children, who lost protective antibody titers to hepatitis B surface antigen (HBs- Ag), this study was conducted.Methods: community-based sero-epidemiologic study was done on 453 healthy 10.5 years old Iranian children, one decade after implementation of a mass hepatitis B vaccination program. A booster vaccination with different dosages was given for children who did not have protective level of anti-hepatitis B surface antigen antibody (anti-HBs). Quantitative serologic responses to different dosages of vaccine were compared using X2 statistical test.Results: A total of 42% children (191 of 453) children had low concentration (<10IU/L) of anti HBs antibody, 18.5% (84 of 453) were susceptible (antibody titer <2IU/L). 87.2% of 165 nonprotected-boostered vaccines showed IMMUNOLOGIC MEMORY to different doses of booster, and developed protective antibody titer two weeks later. The differences between pre- (3.48 ±3.39; mean±SD) and post- (153±163.84) vaccination antibody titers were significant (p=0.000). Antibody titers achieved by different doses of vaccine had significant proportion to vaccine doses. No hepatitis B infection markers were detected in those children who were not sero-protected and did not respond to booster dose of vaccination.Conclusion: According to these findings, universal hepatitis B vaccination program at birth provides adequate protection against hepatitis B virus infection at least for 10 years. It might suggest that booster vaccination is not recommended, but further follow-up studies at adulthood age group are recommended.

Cites

اثر حفاظتی واکسن هپاتیت B در کودکان واکسینه شده 12 تا 24 ماهه شهرستان سنندج

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APA: Copy

SAFAAR, M.J., & REZAEI, M.S.. (2004). LONG-TERM ANTIBODY RESPONSE AND IMMUNOLOGIC MEMORY IN CHILDREN IMMUNIZED WITH HEPATITIS B VACCINE AT BIRTH. KOOMESH, 5(1-2), 63-71. SID. https://sid.ir/paper/37011/en

Vancouver: Copy

SAFAAR M.J., REZAEI M.S.. LONG-TERM ANTIBODY RESPONSE AND IMMUNOLOGIC MEMORY IN CHILDREN IMMUNIZED WITH HEPATITIS B VACCINE AT BIRTH. KOOMESH[Internet]. 2004;5(1-2):63-71. Available from: https://sid.ir/paper/37011/en

IEEE: Copy

M.J. SAFAAR, and M.S. REZAEI, “LONG-TERM ANTIBODY RESPONSE AND IMMUNOLOGIC MEMORY IN CHILDREN IMMUNIZED WITH HEPATITIS B VACCINE AT BIRTH,” KOOMESH, vol. 5, no. 1-2, pp. 63–71, 2004, [Online]. Available: https://sid.ir/paper/37011/en

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