EFFECT OF AQUEOUS EXTRACT OF ORIGANUM VULGARE AND MELILOTUS OFFICINALIS ONPRODUCTION OF NITRIC OXIDE (NO) IN CULTURED VASCULAR ENDOTHELIAL CELLS (MOUSE ENDOTHELIOMA F-2 CELL LINE)

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MAHROOZ; A.; ANSARI M.; SHARIF TABRIZI A.

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2007 | Volume:16 | Issue:55 Page(s): 50-56

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Title

EFFECT OF AQUEOUS EXTRACT OF ORIGANUM VULGARE AND MELILOTUS OFFICINALIS ONPRODUCTION OF NITRIC OXIDE (NO) IN CULTURED VASCULAR ENDOTHELIAL CELLS (MOUSE ENDOTHELIOMA F-2 CELL LINE)

Author(s)

MAHROOZ | A. | A.SARI M. | SHARIF TABRIZI A. | Issue Writer Certificate

Keywords

NITRIC OXIDE (NO)Q3

ORIGANUM VULGAREQ3

MELILOTUS OFFICINALISQ3

MIGRAINEQ2

ENDOTHELIAL CELLSQ3

Abstract

Background and purpose: During recent years, nitric oxide (NO) has been considered as a molecule involved in MIGRAINE headaches. This free radical involves in initiation of MIGRAINE headaches via NO/cGMP signaling pathway and vascular relaxation specially big intracranial arteries. Therefore, we studied the effects of aqueous extract of ORIGANUM VULGARE and MELILOTUS OFFICINALIS prescribed in MIGRAINE treatment in traditional & modem medicine, on NO level in cultured ENDOTHELIAL CELLS.Materials and Methods: Each crude herb (25g) was mixed with 200 ml distilled water. End extract obtained after filtering and drying. ENDOTHELIAL CELLS propagated in DMEM medium containing 10% FCS and 1-2% penicillin-streptomycin. The nitrite concentration was measured as an indicator of nitric oxide production according to the Griess reaction and with ELISA in 540nm.Results: Concentrations of 100, 200 and 400 µg/ml of ORIGANUM VULGARE, reduced NO levels compared with control to 13.1 % (p<0.05), 25.8% (p<0.01) and 33.9% (p<0.001) respectively. However, despite our expectation MELILOTUS OFFICINALIS increased NO level. The concentrations of 100, 200 and 400 µg/ml of the herb, increased NO levels to 12.7 (p<0.05), 36.5% (p<0.001) & 72.9% (p<0.001) respectively.Conclusion: We concluded that aqueous extract of ORIGANUM VULGARE probably decreases MIGRAINE headaches by reducing NO and aqueous extract of MELILOTUS OFFICINALIS does not act through this mechanism.

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APA: Copy

MAHROOZ,, A., ANSARI, M., & SHARIF TABRIZI, A.. (2007). EFFECT OF AQUEOUS EXTRACT OF ORIGANUM VULGARE AND MELILOTUS OFFICINALIS ONPRODUCTION OF NITRIC OXIDE (NO) IN CULTURED VASCULAR ENDOTHELIAL CELLS (MOUSE ENDOTHELIOMA F-2 CELL LINE). JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 16(55), 50-56. SID. https://sid.ir/paper/44581/en

Vancouver: Copy

MAHROOZ, A., ANSARI M., SHARIF TABRIZI A.. EFFECT OF AQUEOUS EXTRACT OF ORIGANUM VULGARE AND MELILOTUS OFFICINALIS ONPRODUCTION OF NITRIC OXIDE (NO) IN CULTURED VASCULAR ENDOTHELIAL CELLS (MOUSE ENDOTHELIOMA F-2 CELL LINE). JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2007;16(55):50-56. Available from: https://sid.ir/paper/44581/en

IEEE: Copy

A. MAHROOZ,, M. ANSARI, and A. SHARIF TABRIZI, “EFFECT OF AQUEOUS EXTRACT OF ORIGANUM VULGARE AND MELILOTUS OFFICINALIS ONPRODUCTION OF NITRIC OXIDE (NO) IN CULTURED VASCULAR ENDOTHELIAL CELLS (MOUSE ENDOTHELIOMA F-2 CELL LINE),” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 55, pp. 50–56, 2007, [Online]. Available: https://sid.ir/paper/44581/en

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