APPLICATION OF L-ARGININE AS NITRIC OXIDE INDUCER AND INDOMETHACIN AS PROSTAGLANDIN INHIBITOR IN BALB/C MICE INFECTED WITH LEISHMANIA MAJOR MRHO/IR/75/ER

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GHASEMI F.; NAHREVANIAN H.

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Journal: Annals of Military and Health Sciences Research Year:2013 | Volume:11 | Issue:1 (SERIAL NUMBER 41) Page(s): 1-10

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Title

APPLICATION OF L-ARGININE AS NITRIC OXIDE INDUCER AND INDOMETHACIN AS PROSTAGLANDIN INHIBITOR IN BALB/C MICE INFECTED WITH LEISHMANIA MAJOR MRHO/IR/75/ER

Author(s)

GHASEMI F. | NAHREVANIAN H. | Issue Writer Certificate

Keywords

LEISHMANIA MAJORQ2

NITRIC OXIDEQ2

INDOMETHACINQ2

L-ARGININEQ2

Abstract

Background: Leishmaniasis is one of the health problems in. This study is designed to inhibit PG production by INDOMETHACIN and induce NO by L- Arginine precursor in L. major infected Balb/c mice.Materials and methods: This was an experimental study. Animals, Male inbred Balb/c mice were used in this study. The total number of animals used in this experiment was 48 Balb/c mice, divided into 6 groups (n=8 mice/group) including Group 1 (naive), Group 2 (L. major + 0.4% Ethanol), Group 3 (L. major + INDOMETHACIN), Group 4 (L. major + DW), Group 5 (L. major + L- Arginine) and Group 6 (L. major + INDOMETHACIN + LArginine). In addition to serum, liver and spleen suspensions were investigated for NO induction by using Griess microassay. The data was analyzed by Analysis of Variances (ANOVA) and Student’s t-test using Graph Pad Prism Software.Results: The results indicated that production of NO was inhibited in infected Balb/c mice by L. major as compared with naive animals (Group 1). INDO as inhibitor PG (Group 2) showed their ability to elevate RNI levels in infect animals. INDO showed anti-leishmanial activity, as these compounds reduced the lesion sizes (P<0.001). INDO as inhibitor PG (Group 3) showed ability to decrease PG levels in infect animals.Conclusion: Our data may indicate a possible role for L-Arg and INDO as novel drug targets for the treatment of cutaneous leishmaniasis in mouse model.

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APA: Copy

GHASEMI, F., & NAHREVANIAN, H.. (2013). APPLICATION OF L-ARGININE AS NITRIC OXIDE INDUCER AND INDOMETHACIN AS PROSTAGLANDIN INHIBITOR IN BALB/C MICE INFECTED WITH LEISHMANIA MAJOR MRHO/IR/75/ER. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, 11(1 (SERIAL NUMBER 41)), 1-10. SID. https://sid.ir/paper/96815/en

Vancouver: Copy

GHASEMI F., NAHREVANIAN H.. APPLICATION OF L-ARGININE AS NITRIC OXIDE INDUCER AND INDOMETHACIN AS PROSTAGLANDIN INHIBITOR IN BALB/C MICE INFECTED WITH LEISHMANIA MAJOR MRHO/IR/75/ER. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH[Internet]. 2013;11(1 (SERIAL NUMBER 41)):1-10. Available from: https://sid.ir/paper/96815/en

IEEE: Copy

F. GHASEMI, and H. NAHREVANIAN, “APPLICATION OF L-ARGININE AS NITRIC OXIDE INDUCER AND INDOMETHACIN AS PROSTAGLANDIN INHIBITOR IN BALB/C MICE INFECTED WITH LEISHMANIA MAJOR MRHO/IR/75/ER,” ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, vol. 11, no. 1 (SERIAL NUMBER 41), pp. 1–10, 2013, [Online]. Available: https://sid.ir/paper/96815/en

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