EFFICACY OF GINGER IN PATIENTS UNCONTROLLED ON STANDARD MODERATE ASTHMA TREATMENT

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FARZIN DAVOOD; SHARIFPOUR ALI; MANSOURI SEYEDEH NAZANIN; ALIYALI MASUD; ABEDI SIAVASH

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2012 | Volume:21 | Issue:SUPPLEMENT 1 Page(s): 139-151

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Title

EFFICACY OF GINGER IN PATIENTS UNCONTROLLED ON STANDARD MODERATE ASTHMA TREATMENT

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Keywords

MODERATE PERSISTENT ASTHMAQ2

CROSS-OVER TRIALQ2

ADD-ON THERAPYQ2

GINGER139Q2

Abstract

Background and purpose: The goal of asthma therapy is to achieve clinical control and near normal lung functions. Many patients with MODERATE PERSISTENT ASTHMA fail to achieve this goal with a low dose of inhaled corticosteroid (ICS) plus long-acting β2 agonist (LABA). In the present study, we have checked whether another controller medication (in the form of ginger capsule) add on to ICSlow dose+ LABA helps in achieving the asthma goal or not.Materials and methods: Thirty two adult asthmatics (17 male and 15 female) completed a 10 week trial consisting of a 1 week single blind run in period, during which placebo (250 mg capsule of lactose 3 times a day) was added to usual treatment (inhaled beclomethasone diproprionate 200 mg/twice daily plus salmeterol 50 mg/twice daily), a 4 week double blind active treatment period in which subjects received ginger (250 mg capsule of powdered ginger 3 times a day) or placebo capsule, a single blind 1 week washout period receiving placebo and a final 4 week double blind cross-over active treatment period. The primary efficacy variable was the forced expiratory volume at 1 second (FEV1); secondary efficacy variables were the peak expiratory flow (PEF) and the asthma control test (ACT) scores. These variables were measured at the completion of each phase, i.e. the end of weeks 1, 5, 6 and 10. Statistical comparisons of all variables were made by two-way analysis of variance (ANOVA) with patient, period, and treatment as fixed factors. P< 0.05 was considered statistically significant.Results: All the patients of the ginger group had significant improvement in FEV1 , PEF and ACT scores (P<0.001) at the end of 10 weeks. Mean (95% CI) measurements for ginger vs placebo treatment periods were 1.99 vs 1.49 (0.32 to 0.68) L for FEV1, 255.8 vs 205.4 (27.1 to 73.8) L min-1 for PEF and 20.6 vs 17.3 (2.77 to 3.73) for ACT scores. There was a similar frequency of minor adverse effects reported during placebo (13%) and ginger (16%) treatments (P>0.05).Conclusion: Powdered ginger rhizome capsule as an add on to inhaled corticosteroid and long-acting b2 agonist is effective in the improvement of FEV1, PEF, and ACT scores of the patients of a moderate type of persistent asthma uncontrolled on standard treatment.

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APA: Copy

FARZIN, DAVOOD, SHARIFPOUR, ALI, MANSOURI, SEYEDEH NAZANIN, ALIYALI, MASUD, & ABEDI, SIAVASH. (2012). EFFICACY OF GINGER IN PATIENTS UNCONTROLLED ON STANDARD MODERATE ASTHMA TREATMENT. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 21(SUPPLEMENT 1), 139-151. SID. https://sid.ir/paper/44732/en

Vancouver: Copy

FARZIN DAVOOD, SHARIFPOUR ALI, MANSOURI SEYEDEH NAZANIN, ALIYALI MASUD, ABEDI SIAVASH. EFFICACY OF GINGER IN PATIENTS UNCONTROLLED ON STANDARD MODERATE ASTHMA TREATMENT. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;21(SUPPLEMENT 1):139-151. Available from: https://sid.ir/paper/44732/en

IEEE: Copy

DAVOOD FARZIN, ALI SHARIFPOUR, SEYEDEH NAZANIN MANSOURI, MASUD ALIYALI, and SIAVASH ABEDI, “EFFICACY OF GINGER IN PATIENTS UNCONTROLLED ON STANDARD MODERATE ASTHMA TREATMENT,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. SUPPLEMENT 1, pp. 139–151, 2012, [Online]. Available: https://sid.ir/paper/44732/en

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