COMPARING THE EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF VIOLA ODORATA AND MELATONIN ON TUMOR GROWTH AND NF-KB, TNFR1, AND VCAM-1 EXPRESSION RATES IN 4T1 BREAST CANCER MODEL: AN IN VIVO STUDY

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ALIPANAH HIVA; BIGDELI MOHAMMAD REZA; ESMAEILI MOHAMMAD ALI; AKBARI MOHAMMAD ESMAEIL

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Journal: Journal of Mazandaran University of Medical Sciences Year:2017 | Volume:27 | Issue:147 Page(s): 25-40

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Title

COMPARING THE EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF VIOLA ODORATA AND MELATONIN ON TUMOR GROWTH AND NF-KB, TNFR1, AND VCAM-1 EXPRESSION RATES IN 4T1 BREAST CANCER MODEL: AN IN VIVO STUDY

Author(s)

ALIPANAH HIVA | BIGDELI MOHAMMAD REZA | ESMAEILI MOHAMMAD ALI | AKBARI MOHAMMAD ESMAEIL | Issue Writer Certificate

Keywords

MELATONINQ2

NF-KBQ1

TNFR1Q1

VCAM-1Q1

VIOLAQ1

Abstract

Background and purpose: VIOLA odorata is a medical plant used in the treatment of hepatic disorders and relieving cancer pain. MELATONIN (Mel) can act as an antioxidant and prevent cells against oxidative stress. This compound has a direct inhibitory effect on cancer cell proliferation. In the present study, we performed an in-vivo study to evaluate the effects of VIOLA odorata hydro-alcoholic extract (VOE) and MEL on tumor growth and NF-KB, TNFR1, and VCAM-1 expression rate in 4T1 breast cancer model.Materials and methods: In this experimental study, 4T1 cells, which were cultured in-vitro, were harvested and put in a serum-free suspension medium. The animals (five groups, n=5) received subcutaneous injections of 0.1 ml of cell suspension (0.8 million cells) in the right mammary gland or hind flank. The implanted BALB/c mice with 4T1 cells were treated with different concentrations of VOE (50, 150, and 250 mg/kg) and Mel (40 mg/kg) for 21 days. The control group received distilled water. The mice were sacrificed on day 22. NF-KB, TNFR1, and VCAM-1 expression rate was measured by Western Blotting technique. To analyze the data, ANOVA test was run in SPSS, version 16.esults: The size of tumors in Mel (P=0.000) and VOE250 (P=0.0001) treated mice was smaller compared to that of the control group. Our results indicated that Mel (P=0.022) and VOE250 (P=0.02) increased TNFR1 expression. On the other hand, Mel (P=0.034) and VOE150 (P=0.04) decreased VCAM-1 expression in the 4T1 breast cancer model. Unlike the Mel group, NF-KB expression reduced in the group receiving VOE250 compared to that of the control group (P=0.012).Conclusion: It seems that VOE and Mel can reduce the rate of tumor growth in 4T1 breast cancer model by decreasing the expression of VCAM-1 and NF-KB and enhancing the expression of TNFR1.

Cites

The Effect of Aromatherapy by Inhalation and Massage on Radiotherapy-induced Fatigue in Patients With Cancer

References

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APA: Copy

ALIPANAH, HIVA, BIGDELI, MOHAMMAD REZA, ESMAEILI, MOHAMMAD ALI, & AKBARI, MOHAMMAD ESMAEIL. (2017). COMPARING THE EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF VIOLA ODORATA AND MELATONIN ON TUMOR GROWTH AND NF-KB, TNFR1, AND VCAM-1 EXPRESSION RATES IN 4T1 BREAST CANCER MODEL: AN IN VIVO STUDY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 27(147), 25-40. SID. https://sid.ir/paper/44914/en

Vancouver: Copy

ALIPANAH HIVA, BIGDELI MOHAMMAD REZA, ESMAEILI MOHAMMAD ALI, AKBARI MOHAMMAD ESMAEIL. COMPARING THE EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF VIOLA ODORATA AND MELATONIN ON TUMOR GROWTH AND NF-KB, TNFR1, AND VCAM-1 EXPRESSION RATES IN 4T1 BREAST CANCER MODEL: AN IN VIVO STUDY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;27(147):25-40. Available from: https://sid.ir/paper/44914/en

IEEE: Copy

HIVA ALIPANAH, MOHAMMAD REZA BIGDELI, MOHAMMAD ALI ESMAEILI, and MOHAMMAD ESMAEIL AKBARI, “COMPARING THE EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF VIOLA ODORATA AND MELATONIN ON TUMOR GROWTH AND NF-KB, TNFR1, AND VCAM-1 EXPRESSION RATES IN 4T1 BREAST CANCER MODEL: AN IN VIVO STUDY,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 147, pp. 25–40, 2017, [Online]. Available: https://sid.ir/paper/44914/en

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