DRD2 DOPAMINE RECEPTOR AND IL-1β GENE EXPRESSIONCHANGES INVOLVED IN WOUND HEALING IN TYPE 2 DIABETICPATIENTS WITH FOOT ULCER

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EBRAHIMZADEH NEDA; VASEGHI HAJAR; RIGI GARSHASB; ESMAEELI DJAVID GHOLAMREZA; MOHAMMAD GANJI SHAHLA; FARHOUD AMIRREZA; PORNOUR MAJID

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:28 | Issue:162 Page(s): 47-58

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Title

DRD2 DOPAMINE RECEPTOR AND IL-1β GENE EXPRESSIONCHANGES INVOLVED IN WOUND HEALING IN TYPE 2 DIABETICPATIENTS WITH FOOT ULCER

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Keywords

DIABETESQ2

FOOT ULCERQ2

DOPAMINE RECEPTORQ1

GENE EXPRESSION CHANGESQ1

IL-1βQ1

Abstract

Background and purpose: Diabetic FOOT ULCER is a complication of type 2 DIABETES. Variousfactors, such as changes in the level of cytokines (especially IL-1β ) can interfere with the development ofdiabetic FOOT ULCER. Several factors affect the level of IL-1β levels, including the rate of neurotransmitter, especially dopamine and its receptors. The aim of this study was to investigate the changes in IL-1β anddopamine DRD2 receptor in peripheral blood mononuclear cells (PBMCs) in diabetic FOOT ULCERs. Materials and methods: In a cross sectional comparative study, peripheral blood samples werecollected from 31 subjects with diabetic FOOT ULCER, 29 without ulcer, and 25 healthy individuals (control). Total mRNA was extracted from PBMCs and cDNA was synthesized to study the DRD2 and IL-1β geneexpression variations by real time PCR. Concentration of IL-1β was also investigated in sera. Results: Significant decrease was seen in gene expression and sera concentration of IL-1β inPBMCs in diabetic patients with FOOT ULCER. There was also a significant reduction in the expression ofDRD2 receptor gene in patients with and without FOOT ULCER. Conclusion: Reduction of IL-1β expression seems to be related to changes in the expression ofDRD2 receptor gene. Therefore, after supplementary studies, reducing the expression of DRD2 could beregarded as a prognostic factor and as an effective factor in the spread of diabetic FOOT ULCER.

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APA: Copy

EBRAHIMZADEH, NEDA, VASEGHI, HAJAR, RIGI, GARSHASB, ESMAEELI DJAVID, GHOLAMREZA, MOHAMMAD GANJI, SHAHLA, FARHOUD, AMIRREZA, & PORNOUR, MAJID. (2018). DRD2 DOPAMINE RECEPTOR AND IL-1β GENE EXPRESSIONCHANGES INVOLVED IN WOUND HEALING IN TYPE 2 DIABETICPATIENTS WITH FOOT ULCER. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(162 ), 47-58. SID. https://sid.ir/paper/45038/en

Vancouver: Copy

EBRAHIMZADEH NEDA, VASEGHI HAJAR, RIGI GARSHASB, ESMAEELI DJAVID GHOLAMREZA, MOHAMMAD GANJI SHAHLA, FARHOUD AMIRREZA, PORNOUR MAJID. DRD2 DOPAMINE RECEPTOR AND IL-1β GENE EXPRESSIONCHANGES INVOLVED IN WOUND HEALING IN TYPE 2 DIABETICPATIENTS WITH FOOT ULCER. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;28(162 ):47-58. Available from: https://sid.ir/paper/45038/en

IEEE: Copy

NEDA EBRAHIMZADEH, HAJAR VASEGHI, GARSHASB RIGI, GHOLAMREZA ESMAEELI DJAVID, SHAHLA MOHAMMAD GANJI, AMIRREZA FARHOUD, and MAJID PORNOUR, “DRD2 DOPAMINE RECEPTOR AND IL-1β GENE EXPRESSIONCHANGES INVOLVED IN WOUND HEALING IN TYPE 2 DIABETICPATIENTS WITH FOOT ULCER,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 162 , pp. 47–58, 2018, [Online]. Available: https://sid.ir/paper/45038/en

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