EFFECT OF VITEX AGNUS-CASTUS EXTRACT ON LEARNING AND MEMORY IN OVARIECTOMIZED RATS

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HONARI NAJME; POURABOULI IRAN; HAKIMIZADEH ELHAM; SHAMSIZADEH ALI; AMIN FATEMEH; ALLAHTAVAKOLI MOHAMMAD

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2012 | Volume:22 | Issue:93 Page(s): 2-10

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Title

EFFECT OF VITEX AGNUS-CASTUS EXTRACT ON LEARNING AND MEMORY IN OVARIECTOMIZED RATS

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Keywords

VITEX AGNUS CASTUSQ2

MEMORY AND LEARNINGQ1

OVARIECTOMYQ2

MENOPAUSEQ2

Abstract

Background and purpose: MENOPAUSE is associated with the cessation of ovarian activities and hypoestrogenemia causing many complications including learning and memory disorders. Recent studies have shown that these cognitive disabilities are due to the diminished neuroprotective and neurotrophic effects of estrogen and accordingly, estrogen therapy may prevent or overcome them. Since estrogen therapy has many side effects, using of other alternatives is of interest. The purpose of this study was to investigate the therapeutic effects of VITEX AGNUS CASTUSa, a genus of tropical and sub-tropical flowering plants containing phytoestrogens, on learning and memory disorders in ovariectomized rats.Materials and methods: Forty two ovariectomized female Wistar rats (150 to 200g) were divided into five groups of seven as follows: control group, OVARIECTOMY group, VITEX AGNUS CASTUS extract at 8 mg/kg, VITEX AGNUS CASTUS extract at 80 mg/kg, estradiol valerat at 40 mg/kg, and combination of tamoxifen (100 mg/kg) and VITEX AGNUS CASTUS extract (80 mg/kg). The rats received these treatments orally for three months after OVARIECTOMY. At the end of the therapeutic period, learning ability of the rats was measured using a shuttle box.Results: Compared to the OVARIECTOMY group, estradiol valerat at 40 mg/kg, VITEX AGNUS CASTUS extracts at 8 or 80 mg/kg and control group increased the level of the STLr factor and reverse results were observed for the TDC (Time spent in Dark Compartment) factor. However, the frequency of shock was diminished only in rats which VITEX AGNUS CASTUS extracts at 80 mg/kg.Conclusion: Based on our data, VITEX AGNUS CASTUS extract showed estrogen-like effects and improved memory disorder in ovariectomized female rats.

Cites

Effect of hydroalcoholic chamomile (Atricaria chamomilla) extract on avoidance memory

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APA: Copy

HONARI, NAJME, POURABOULI, IRAN, HAKIMIZADEH, ELHAM, SHAMSIZADEH, ALI, AMIN, FATEMEH, & ALLAHTAVAKOLI, MOHAMMAD. (2012). EFFECT OF VITEX AGNUS-CASTUS EXTRACT ON LEARNING AND MEMORY IN OVARIECTOMIZED RATS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 22(93), 2-10. SID. https://sid.ir/paper/45092/en

Vancouver: Copy

HONARI NAJME, POURABOULI IRAN, HAKIMIZADEH ELHAM, SHAMSIZADEH ALI, AMIN FATEMEH, ALLAHTAVAKOLI MOHAMMAD. EFFECT OF VITEX AGNUS-CASTUS EXTRACT ON LEARNING AND MEMORY IN OVARIECTOMIZED RATS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;22(93):2-10. Available from: https://sid.ir/paper/45092/en

IEEE: Copy

NAJME HONARI, IRAN POURABOULI, ELHAM HAKIMIZADEH, ALI SHAMSIZADEH, FATEMEH AMIN, and MOHAMMAD ALLAHTAVAKOLI, “EFFECT OF VITEX AGNUS-CASTUS EXTRACT ON LEARNING AND MEMORY IN OVARIECTOMIZED RATS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 93, pp. 2–10, 2012, [Online]. Available: https://sid.ir/paper/45092/en

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