BRIEF REPORT: EVALUATION OF HUMAN LEUKOCYTE ANTIGEN-G AND INTERLEUKIN-10 EXPRESSION IN HIV POSITIVE PATIENTS AND HEALTHY SUBJECTS

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OMRANI NAVA VERSA; ABEDIAN KENARI SAEID; YAZDANI CHARATI JAMSHID; YAHYAPOUR YOUSEF; SADAT SHOBEIRI SAEIDEH; MOHAMMADI MASOUD; RANJBARAN HOSSEIN; ABEDI SIAVASH

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Title

BRIEF REPORT: EVALUATION OF HUMAN LEUKOCYTE ANTIGEN-G AND INTERLEUKIN-10 EXPRESSION IN HIV POSITIVE PATIENTS AND HEALTHY SUBJECTS

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Keywords

HLA-GQ1

HIVQ2

IL-10Q1

Abstract

Background and purpose: HILA-G is an immunomodulatory molecule and alteration of its expression is prevalent during viral infections. HLA-G expression in HIV-positive patients has been inconsistent between different studies and some suggest that Interleukin-10 (IL-10) influences the expression of HLA-G. The aim of this research was to investigate the expression of IL-10 in HIV-positive patients and its relation with TCD4+lymphocytes.Materials and methods: In a case-control study, 20 HIV-positive patients, attending the Behavioral Consultation Center affiliated with Mazandaran University of Medical Sciences, were selected and 20 healthy volunteers were also enrolled. Expression of HLA-G was determined by Real-Time PCR.TCD4+count and IL-10 concentration were evaluated by flow cytometry and ELISA, respectively.Results: HLA-G gene expression was significantly different between the two groups (P<0.05).IL-10 concentration increased in patients and a revers relation was seen between TCD4+cell count and IL-10 (r=-0.4, P=0.1).Conclusion: The results showed that the expression of HLA-G is deregulated during HIV infection and IL-10 could be considered as a biomarker of disease progression.

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APA: Copy

OMRANI NAVA, VERSA, ABEDIAN KENARI, SAEID, YAZDANI CHARATI, JAMSHID, YAHYAPOUR, YOUSEF, SADAT SHOBEIRI, SAEIDEH, MOHAMMADI, MASOUD, RANJBARAN, HOSSEIN, & ABEDI, SIAVASH. (2016). BRIEF REPORT: EVALUATION OF HUMAN LEUKOCYTE ANTIGEN-G AND INTERLEUKIN-10 EXPRESSION IN HIV POSITIVE PATIENTS AND HEALTHY SUBJECTS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 26(143), 230-234. SID. https://sid.ir/paper/45252/en

Vancouver: Copy

OMRANI NAVA VERSA, ABEDIAN KENARI SAEID, YAZDANI CHARATI JAMSHID, YAHYAPOUR YOUSEF, SADAT SHOBEIRI SAEIDEH, MOHAMMADI MASOUD, RANJBARAN HOSSEIN, ABEDI SIAVASH. BRIEF REPORT: EVALUATION OF HUMAN LEUKOCYTE ANTIGEN-G AND INTERLEUKIN-10 EXPRESSION IN HIV POSITIVE PATIENTS AND HEALTHY SUBJECTS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;26(143):230-234. Available from: https://sid.ir/paper/45252/en

IEEE: Copy

VERSA OMRANI NAVA, SAEID ABEDIAN KENARI, JAMSHID YAZDANI CHARATI, YOUSEF YAHYAPOUR, SAEIDEH SADAT SHOBEIRI, MASOUD MOHAMMADI, HOSSEIN RANJBARAN, and SIAVASH ABEDI, “BRIEF REPORT: EVALUATION OF HUMAN LEUKOCYTE ANTIGEN-G AND INTERLEUKIN-10 EXPRESSION IN HIV POSITIVE PATIENTS AND HEALTHY SUBJECTS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 143, pp. 230–234, 2016, [Online]. Available: https://sid.ir/paper/45252/en

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