SERUM LEVEL AND RS1800799 POLYMORPHISM OF MGP GENE PROMOTER IN PATIENTS WITH CORONARY ARTERIES STENOSIS

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MOHAMMADI ASGHAR; HOSSEINI FARD SEYYEDREZA; ROUSTAZADEH ABAZAR; NAJAFI MOHAMMAD; AMIRFARHANGI ABDOLLAH

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Journal: Journal of Mazandaran University of Medical Sciences Year:2017 | Volume:26 | Issue:144 Page(s): 144-151

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Title

SERUM LEVEL AND RS1800799 POLYMORPHISM OF MGP GENE PROMOTER IN PATIENTS WITH CORONARY ARTERIES STENOSIS

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Keywords

STENOSISQ1

MGPQ1

RS 1800799 POLYMORPHISMQ2

Abstract

Background and purpose: Coronary artery STENOSIS is a progressive process associated with artery calcification. Although the role of matrix Gla protein (MGP) is not completely clear but its expression in vascular smooth muscle cells (VSMCs) and sub-endothelial macrophages suggests a role in vascular calcification. The rs1800799 is one of the polymorphisms oriented within transcription factor elements in the promoter region of the MGP gene that may modify MGP expression patterns resulting in artery calcification. In this study, we examined the serum level and rs1800799 polymorphism of MGP gene promoter in patients with STENOSIS of coronary artery in Tehran.Materials and methods: One hundred sixty three individuals undergoing coronary angiography were divided into two groups: patients (n=100) and controls (n=63). The lipid profile, serum MGP concentration and rs1800799 genotypes were measured by routine laboratory, ELIZA, and RFLP-PCR assays, respectively.Results: In this study, we observed positive relationships between the two groups in LDL, total cholesterol, and TG levels (P<0.05). The HDL, BMI, history of renal disease, diastolic blood pressure and systolic blood pressure were not significantly different between the patients and controls (P>0.05). Also, genotype and allele distributions did not differ significantly between the cases and controls (P>0.05). Furthermore, the serum levels of MGP were not significantly different between genotypes (P>0.1). Conclusion: In this study, the rs1800799 genotype distribution and serum MGP value were not significantly associated with coronary heart disease. Moreover, the serum MGP level showed no major role in the progression of coronary artery STENOSIS.

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APA: Copy

MOHAMMADI, ASGHAR, HOSSEINI FARD, SEYYEDREZA, ROUSTAZADEH, ABAZAR, NAJAFI, MOHAMMAD, & AMIRFARHANGI, ABDOLLAH. (2017). SERUM LEVEL AND RS1800799 POLYMORPHISM OF MGP GENE PROMOTER IN PATIENTS WITH CORONARY ARTERIES STENOSIS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 26(144), 144-151. SID. https://sid.ir/paper/45377/en

Vancouver: Copy

MOHAMMADI ASGHAR, HOSSEINI FARD SEYYEDREZA, ROUSTAZADEH ABAZAR, NAJAFI MOHAMMAD, AMIRFARHANGI ABDOLLAH. SERUM LEVEL AND RS1800799 POLYMORPHISM OF MGP GENE PROMOTER IN PATIENTS WITH CORONARY ARTERIES STENOSIS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;26(144):144-151. Available from: https://sid.ir/paper/45377/en

IEEE: Copy

ASGHAR MOHAMMADI, SEYYEDREZA HOSSEINI FARD, ABAZAR ROUSTAZADEH, MOHAMMAD NAJAFI, and ABDOLLAH AMIRFARHANGI, “SERUM LEVEL AND RS1800799 POLYMORPHISM OF MGP GENE PROMOTER IN PATIENTS WITH CORONARY ARTERIES STENOSIS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 144, pp. 144–151, 2017, [Online]. Available: https://sid.ir/paper/45377/en

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