SURFACE CONTAMINATION WITH CYCLOPHOSPHAMIDE AND IPHOSPHAMIDE IN CHEMOTHERAPY CENTERS

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DELJOU HAMIDEH; ASSARI MOHAMMAD JAVAD; BAHRAMI ABDOLRAMAN; ZOLHAVARIEH MOHAMMAD

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Title

SURFACE CONTAMINATION WITH CYCLOPHOSPHAMIDE AND IPHOSPHAMIDE IN CHEMOTHERAPY CENTERS

Author(s)

DELJOU HAMIDEH | ASSARI MOHAMMAD JAVAD | BAHRAMI ABDOLRAMAN | ZOLHAVARIEH MOHAMMAD | Issue Writer Certificate

Keywords

DRUG THERAPYQ3

CYCLOPHOSPHAMIDEQ2

IFOSFAMIDEQ1

OCCUPATIONAL EXPOSUREQ2

ENVIRONMENTALMONITORINGQ2

HOSPITALSQ1

Abstract

Background and purpose: CYCLOPHOSPHAMIDE and IFOSFAMIDE are two most widely used andhazardous drugs in chemotherapy centers. This study aimed at determining surface contamination withcyclophosphamide and iphosphamide in chemotherapy centers. Materials and methods: This descriptive cross-sectional study was carried out in threechemotherapy centers affiliated with Hamedan University of Medical Sciences, Iran 2016. Twenty eightsamples were collected from contaminated surfaces. The samples were then prepared by solid phaseextraction and analyzed by HPLC/UV apparatus. Results: The mean values for surface contamination of CYCLOPHOSPHAMIDE and IFOSFAMIDE were57. 28 ± 63. 8 and 44. 15 ± 5. 5 ng/cm2, respectively. The highest levels of contamination with both drugswere observed at exhaust hood surfaces and the lowest level of contamination was seen in nursing stationand staff resting place. The clothes and gloves of nurses were also found to be contaminated. Conclusion: Daily number of medications, the location of drug preparation room and injectionroom, nursing station, staff resting place, daily cleaning programs, and repairing and maintenance ofventilation systems were amongst the major factors affecting surface contamination in chemotherapycenters.

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APA: Copy

DELJOU, HAMIDEH, ASSARI, MOHAMMAD JAVAD, BAHRAMI, ABDOLRAMAN, & ZOLHAVARIEH, MOHAMMAD. (2018). SURFACE CONTAMINATION WITH CYCLOPHOSPHAMIDE AND IPHOSPHAMIDE IN CHEMOTHERAPY CENTERS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(161 ), 133-137. SID. https://sid.ir/paper/45478/en

Vancouver: Copy

DELJOU HAMIDEH, ASSARI MOHAMMAD JAVAD, BAHRAMI ABDOLRAMAN, ZOLHAVARIEH MOHAMMAD. SURFACE CONTAMINATION WITH CYCLOPHOSPHAMIDE AND IPHOSPHAMIDE IN CHEMOTHERAPY CENTERS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;28(161 ):133-137. Available from: https://sid.ir/paper/45478/en

IEEE: Copy

HAMIDEH DELJOU, MOHAMMAD JAVAD ASSARI, ABDOLRAMAN BAHRAMI, and MOHAMMAD ZOLHAVARIEH, “SURFACE CONTAMINATION WITH CYCLOPHOSPHAMIDE AND IPHOSPHAMIDE IN CHEMOTHERAPY CENTERS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 161 , pp. 133–137, 2018, [Online]. Available: https://sid.ir/paper/45478/en

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