BRIEF REPORT: EVALUATING THE MOST COMMON MUTATION IN BRCAI AND BRCA2 GENES IN WOMEN WHO HAD MOTHERS WITH BREST CANCER AND CONTROLS

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SARVAR FAEZEH; NEKOUIAN REZA; SAEI RAD SAMIRA; GHARAVI MOHAMMAD JAVAD; TEHRANI MOHSEN; SARVARTAHERABADI MARYAM; SHARIF MASOUD; ABEDIAN KENARI SAEID

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2016 | Volume:26 | Issue:141 Page(s): 137-142

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Title

BRIEF REPORT: EVALUATING THE MOST COMMON MUTATION IN BRCAI AND BRCA2 GENES IN WOMEN WHO HAD MOTHERS WITH BREST CANCER AND CONTROLS

Author(s)

Keywords

BREAST NEOPLASMSQ2

BRCA1Q3

MUTATIONQ1

Abstract

Background and purpose: Breast Cancer is one of the health problems in every population.The aim of this study was to determine the frequency of BRCA1 and BRCA2 common MUTATIONs in women whose mothers were diagnosed with breast cancer.Materials and methods: A case–control study was performed in 109 females (less than 40 years of age) who had mothers with breast cancer. For scanning of genomic MUTATIONs in BRCA1 and BRCA2, genes MUTATION analysis was done in BRCA1 (exon2, 20) and BRCA2 (exon11) using Real Time PCR test. We also studied 109 healthy controls without family history of breast cancer.Results: No any MUTATION was found in this population.Conclusion: This study showed no MUTATION in affected and control group. Therefore, other MUTATIONs and genes may have a role in breast cancer pathogenesis in our population.

Cites

Detection of a novel mutations in Exon 11 of BRCA1 gene in the patients with hereditary breast cancer

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APA: Copy

SARVAR, FAEZEH, NEKOUIAN, REZA, SAEI RAD, SAMIRA, GHARAVI, MOHAMMAD JAVAD, TEHRANI, MOHSEN, SARVARTAHERABADI, MARYAM, SHARIF, MASOUD, & ABEDIAN KENARI, SAEID. (2016). BRIEF REPORT: EVALUATING THE MOST COMMON MUTATION IN BRCAI AND BRCA2 GENES IN WOMEN WHO HAD MOTHERS WITH BREST CANCER AND CONTROLS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 26(141), 137-142. SID. https://sid.ir/paper/45609/en

Vancouver: Copy

SARVAR FAEZEH, NEKOUIAN REZA, SAEI RAD SAMIRA, GHARAVI MOHAMMAD JAVAD, TEHRANI MOHSEN, SARVARTAHERABADI MARYAM, SHARIF MASOUD, ABEDIAN KENARI SAEID. BRIEF REPORT: EVALUATING THE MOST COMMON MUTATION IN BRCAI AND BRCA2 GENES IN WOMEN WHO HAD MOTHERS WITH BREST CANCER AND CONTROLS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;26(141):137-142. Available from: https://sid.ir/paper/45609/en

IEEE: Copy

FAEZEH SARVAR, REZA NEKOUIAN, SAMIRA SAEI RAD, MOHAMMAD JAVAD GHARAVI, MOHSEN TEHRANI, MARYAM SARVARTAHERABADI, MASOUD SHARIF, and SAEID ABEDIAN KENARI, “BRIEF REPORT: EVALUATING THE MOST COMMON MUTATION IN BRCAI AND BRCA2 GENES IN WOMEN WHO HAD MOTHERS WITH BREST CANCER AND CONTROLS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 141, pp. 137–142, 2016, [Online]. Available: https://sid.ir/paper/45609/en

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